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Serotonin Receptor 3A antibody (HTR3A) (Internal Region) Primary Antibody

HTR3A Reactivity: Human, Rat EIA, IF, WB Host: Goat Polyclonal unconjugated
Pubmed (2)
Catalog No. ABIN374713
$537.90
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0.1 mg
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Available
  • Target
    Serotonin Receptor 3A (HTR3A)
    Binding Specificity
    • 15
    • 11
    • 8
    • 8
    • 8
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Internal Region
    Reactivity
    • 66
    • 12
    • 11
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Human, Rat
    Host
    • 60
    • 7
    • 1
    Goat
    Clonality
    • 67
    • 1
    Polyclonal
    Conjugate
    • 29
    • 7
    • 5
    • 5
    • 3
    • 3
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This Serotonin Receptor 3A antibody is un-conjugated
    Application
    • 49
    • 41
    • 13
    • 13
    • 11
    • 9
    • 6
    • 5
    • 5
    • 3
    • 3
    • 2
    • 1
    • 1
    Enzyme Immunoassay (EIA), Immunofluorescence (IF), Western Blotting (WB)
    Sequence
    C-GPQDFEKSPR DR
    Specificity
    This antibody is expected to recognize all three reported isoforms (NP_998786.2, NP_000860.2, NP_001155244.1).
    Cross-Reactivity (Details)
    Species reactivity (tested):Human, Rat.
    Purification
    Ammonium Sulphate Precipitation followed by Antigen Affinity Chromatography using the immunizing peptide
    Immunogen
    Peptide with sequence from the internal region of the protein sequence Genename: HTR3A
  • Application Notes
    ELISA: 1/128000. Western Blot: 0.3 - 1 μg/mL.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Concentration
    0.5 mg/mL
    Buffer
    Tris saline, pH ~7.3, 0.02 % Sodium Azide, 0.5 % BSA
    Preservative
    Sodium azide
    Precaution of Use
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freezing and thawing.
    Storage
    4 °C/-20 °C
    Storage Comment
    Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
  • do Amaral, Ueno, Oliveira, Borsonello, Vanzela, Ribeiro, Alves, Barbosa, Carneiro, Boschero: "Reduced expression of SIRT1 is associated with diminished glucose-induced insulin secretion in islets from calorie-restricted rats." in: The Journal of nutritional biochemistry, Vol. 22, Issue 6, pp. 554-9, 2011 (PubMed).

    Lu, Hsieh, Dun, Oprea, Wang, Luo, Lin, Chang, Lee: "Estrogen rapidly modulates 5-hydroxytrytophan-induced visceral hypersensitivity via GPR30 in rats." in: Gastroenterology, Vol. 137, Issue 3, pp. 1040-50, 2009 (PubMed).

  • Target
    Serotonin Receptor 3A (HTR3A)
    Abstract
    HTR3A Antibody Abstract
    Synonyms
    MGC52789, HTR3A, 5-HT3, 5HT3R, HTR3, 5-HT-3, 5-HT3A, 5-HT3R, 5HT3, Htr3, 5-hydroxytryptamine (serotonin) receptor 3A, ionotropic L homeolog, 5-hydroxytryptamine receptor 3A, 5-hydroxytryptamine (serotonin) receptor 3A, htr3a.L, HTR3A, Htr3a
    Background
    5-hydroxytryptamine (serotonin) receptors is a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The 5HT3A receptor is a ligand-gated ion channel, which when activated causes fast, depolarizing responses in neurons. It is a cation-specific, but otherwise relatively nonselective, ion channel.Synonyms: 5-HT3A, 5-HT3R, 5-hydroxytryptamine receptor 3A, Serotonin-gated ion channel receptor
    Gene ID
    3359
    NCBI Accession
    NP_000860
    UniProt
    P46098
    Pathways
    Synaptic Membrane
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