TOLLIP antibody

Catalog No. ABIN377023

Product Details anti-TOLLIP Antibody

Target: TOLLIP (Toll Interacting Protein (TOLLIP))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This TOLLIP antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS)

Specificity: Human Tollip, Does not react to TLR2, TLR4, TLR6, TLR7, TLR8 and TLR10 recombinant proteins Tollip, Toll-interacting protein, is a 30 kDa adaptor protein that is a component of the signaling pathway of IL-1 and Toll-like receptors. Tollip forms a complex with IRAK (IL-1 receptor associated kinase) and inhibits IL-1-induced signaling by blocking IRAK phosphorylation. The co-recruitment of MyD88 triggers IRAK autophosphorylation, which in turn leads to the rapid dissociation of IRAK and Tollip. Tollip is also an important signaling component of the TLR2 and TLR4 pathways by playing an inhibitory role in TLR- mediated cell activation. Tollip also associates with Tom1 (target of Myb1) forming a complex which regulates endosomal trafficking of ubiquitinated proteins. 1-6

Characteristics: Mouse Anti-Human Tollip-UNLB

Purification: Purified

Immunogen: Recombinant Tollip

Clone: SB40a

Isotype: IgG2a

Application Details

Application Notes:

• Applications: Flow Cytometry Immunoblotting Enzyme-Linked-Immunosorbent-Assay (ELISA)
• Working Dilutions: Since applications vary, you should determine the optimum working dilution of the product that is appropriate for your specific need.

Sample Volume: 0,2 mL

Restrictions: For Research Use only

Handling

Concentration: 0.5 mg/mL

Buffer: 0.1 mg purified immunoglobulin in 0.2 mL of borate buffered saline,  pH 8.2. No preservatives or amine-containing buffer salts added

Preservative: Without preservative

Handling Advice: Each reagent is stable for the period shown on the bottle label if stored as directed.

Storage: 4 °C

Storage Comment: Store at 2-8°C

Target Details for TOLLIP

Target: TOLLIP (Toll Interacting Protein (TOLLIP))

Alternative Name: Tollip (TOLLIP Products)

Synonyms: IL-1RAcPIP antibody, 4930403G24Rik antibody, 4931428G15Rik antibody, fk22a02 antibody, im:7145391 antibody, wu:fk22a02 antibody, zgc:76985 antibody, TOLLIP antibody, GB17961 antibody, tollip antibody, tollip1 antibody, tollipa antibody, TOLIP antibody, toll interacting protein antibody, toll-interacting protein antibody, toll-interacting protein-like antibody, toll interacting protein L homeolog antibody, toll interacting protein S homeolog antibody, Toll-interleukine I receptor interacting protein I antibody, TOLLIP antibody, Tollip antibody, tollip antibody, LOC552034 antibody, LOC100169858 antibody, tollip.L antibody, tollip.S antibody, LOC100136122 antibody

Background: Toll-interacting protein, is a 30 kDa adaptor protein that is a component of the signaling pathway of IL-1 and Toll-like receptors. Tollip forms a complex with IRAK (IL-1 receptor associated kinase) and inhibits IL-1-induced signaling by blocking IRAK phosphorylation. The co-recruitment of MyD88 triggers IRAK autophosphorylation, which in turn leads to the rapid dissociation of IRAK and Tollip. Tollip is also an important signaling component of the TLR2 and TLR4 pathways by playing an inhibitory role in TLR-mediated cell activation. Tollip also associates with Tom1 (target of Myb1) forming a complex which regulates endosomal trafficking of ubiquitinated proteins.