Caspase 8 antibody (CASP8) (N-Term)

Details for Product anti-CASP8 Antibody No. ABIN379636
Target
  • casp8-A
  • xCaspase-8
  • casp8
  • CASP8
  • CASP-8
  • FLICE
  • MACH
  • Mch5
  • ALPS2B
  • CAP4
  • Casp-8
  • MCH5
  • caspase-8
  • zgc:92075
  • caspase 8 L homeolog
  • death related ced-3/Nedd2-like protein
  • caspase 8
  • caspase-8
  • caspase-8-like
  • caspase 8, apoptosis-related cysteine peptidase
  • casp8.L
  • LOC661095
  • CASP8
  • LOC5563818
  • casp8
  • LOC100222284
  • Casp8
Binding Specificity
N-Term
25
15
11
9
8
8
7
5
5
5
5
4
4
4
4
4
3
3
3
3
3
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Cow, Human, Monkey, Mouse, Rat
198
80
67
12
11
2
1
Host
Rabbit
185
37
7
2
Clonality
Polyclonal
Conjugate
This Caspase 8 antibody is un-conjugated
22
16
7
3
3
3
3
3
3
2
2
2
2
2
1
1
1
1
1
Application
Immunohistochemistry (IHC)
197
71
69
39
26
22
19
16
13
12
9
7
6
4
1
1
1
1
1
1
Options
Immunogen Recombinant full-length human Caspase 8 protein.

Type of Immunogen: Recombinant protein
Specificity Reacts with a 55 kD protein. Caspase 8 has an N-terminal domain with sequence homology to the death effector domain (DED) of FADD. Caspase 8 binds to DED of FADD. Caspase 8 is activated by association with Fas/FADD death-inducing signaling complex to release two active subunits, p18 and p10 into the cytosol, where they activate other Caspases amplifying the apoptotic signal. This antibody cross reacts with mouse, rat, monkey and cow.
Purification Ig fraction
Target
Alternative Name CASP8 / Caspase 8 (CASP8 Antibody Abstract)
Background Name/Gene ID: CASP8
Subfamily: Cysteine C14
Family: Protease

Synonyms: CASP8, ALPS2B, Apoptotic protease Mch-5, Apoptotic cysteine protease, Casp-8, Caspase-8, CAP4, Caspase 8, MACH, MCH5, MORT1-associated ced-3 homolog, ICE-like apoptotic protease 5, Pro Caspase 8, FADD-like ICE, FLICE, MACH-alpha-1/2/3 protein, MACH-beta-1/2/3/4 protein
Gene ID 841
Pathways Apoptosis, Caspase Cascade in Apoptosis, TLR Signaling, Activation of Innate immune Response, Tube Formation, Positive Regulation of Endopeptidase Activity, Toll-Like Receptors Cascades
Application Notes Optimal working dilution should be determined by the investigator.
Comment

Target Species of Antibody: Human

Restrictions For Research Use only
Format Liquid
Concentration Lot specific
Buffer Buffer contains: 0.05 % sodium azide
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Storage Comment Store at 2-8°C. Do not freeze.