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SUMO4 antibody

SUMO4 Reactivity: Human WB, IHC (p) Host: Rabbit Polyclonal RB7259 unconjugated
Catalog No. ABIN388077
  • Target See all SUMO4 Antibodies
    SUMO4 (Small Ubiquitin Related Modifier 4 (SUMO4))
    Reactivity
    • 55
    • 18
    • 18
    Human
    Host
    • 52
    • 3
    Rabbit
    Clonality
    • 44
    • 11
    Polyclonal
    Conjugate
    • 26
    • 5
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    This SUMO4 antibody is un-conjugated
    Application
    • 39
    • 28
    • 25
    • 7
    • 5
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Purification
    This antibody is purified through a protein A column, followed by peptide affinity purification.
    Immunogen
    This SUMO4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the center region of human SUMO4.
    Clone
    RB7259
    Isotype
    Ig Fraction
    Top Product
    Discover our top product SUMO4 Primary Antibody
  • Application Notes
    WB: 1:1000. WB: 1:1000. IHC-P: 1:50~100
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C,-20 °C
    Storage Comment
    Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
    Expiry Date
    6 months
  • Witt, Witt, Lerche, Labeit, Back, Labeit: "Cooperative control of striated muscle mass and metabolism by MuRF1 and MuRF2." in: The EMBO journal, Vol. 27, Issue 2, pp. 350-60, (2008) (PubMed).

  • Target
    SUMO4 (Small Ubiquitin Related Modifier 4 (SUMO4))
    Alternative Name
    SUMO4 (SUMO4 Products)
    Synonyms
    IDDM5 antibody, SMT3H4 antibody, SUMO-4 antibody, dJ281H8.4 antibody, small ubiquitin-like modifier 4 antibody, small ubiquitin-related modifier 4 antibody, SMT3 suppressor of mif two 3 homolog 4 (S. cerevisiae) antibody, SUMO4 antibody, sumo4 antibody
    Background
    SUMO4 is a member of the SUMO gene family. This family of small ubiquitin-related modifiers covalently modify target lysines in proteins and control the target proteins' subcellular localization, stability, or activity. Upon oxidative stress, SUMO4 conjugates to various anti-oxidant enzymes, chaperones, and stress defense proteins. This protein may also conjugate to NFKBIA, TFAP2A and FOS, negatively regulating their transcriptional activity, and to NR3C1, positively regulating its transcriptional activity. Covalent attachment to SUMO4 substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I. In contrast to SUMO1, SUMO2 and SUMO3, SUMO4 seems to be insensitive to sentrin-specific proteases due to the presence of Pro-90. This may impair processing to mature form and conjugation to substrates. SUMO4 is located in the cytoplasm and specifically modifies IKBA, leading to negative regulation of NF-kappa-B-dependent transcription of the IL12B gene. The M55V substitution has been associated with type I diabetes.
    Molecular Weight
    10685
    Gene ID
    387082
    NCBI Accession
    NP_001002255
    UniProt
    Q6EEV6
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