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PUMA antibody (AA 119-154)

BBC3 Reactivity: Human WB, IF, FACS, IHC (p) Host: Rabbit Polyclonal RB01353 unconjugated
Catalog No. ABIN388112
  • Target See all PUMA (BBC3) Antibodies
    PUMA (BBC3) (BCL2 Binding Component 3 (BBC3))
    Binding Specificity
    • 21
    • 18
    • 16
    • 10
    • 7
    • 7
    • 6
    • 6
    • 6
    • 6
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 119-154
    Reactivity
    • 113
    • 40
    • 39
    • 16
    Human
    Host
    • 109
    • 7
    • 1
    Rabbit
    Clonality
    • 98
    • 19
    Polyclonal
    Conjugate
    • 52
    • 8
    • 8
    • 6
    • 5
    • 5
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This PUMA antibody is un-conjugated
    Application
    • 98
    • 40
    • 39
    • 22
    • 21
    • 16
    • 16
    • 14
    • 13
    • 9
    • 5
    • 3
    • 2
    • 2
    Western Blotting (WB), Immunofluorescence (IF), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Predicted Reactivity
    M, Rat
    Purification
    This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
    Immunogen
    This Puma BH3 Domain antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 119-154 amino acids from human Puma BH3 Domain.
    Clone
    RB01353
    Isotype
    Ig Fraction
    Top Product
    Discover our top product BBC3 Primary Antibody
  • Application Notes
    IF: 1:10~50. WB: 1:1000. IHC-P: 1:10~50. FC: 1:10~50
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C,-20 °C
    Storage Comment
    Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
    Expiry Date
    6 months
  • Vesela, Matalova: "Detection of Bim and Puma in mouse hair follicles using immunofluorescence and TUNEL assay double staining." in: Biotechnic & histochemistry : official publication of the Biological Stain Commission, pp. 1-7, (2015) (PubMed).

  • Target
    PUMA (BBC3) (BCL2 Binding Component 3 (BBC3))
    Alternative Name
    Puma (BBC3 Products)
    Synonyms
    BBC3 antibody, Puma antibody, JFY-1 antibody, JFY1 antibody, PUMA antibody, PUMA/JFY1 antibody, BCL2 binding component 3 antibody, Bcl-2 binding component 3 antibody, BBC3 antibody, Bbc3 antibody, bbc3 antibody
    Background
    PUMA is one of the pro-apoptotic Bcl-2 family members including Bax and Noxa, which are also transcriptional targets of p53. The PUMA gene encodes two BH3 domain-containing proteins termed PUMA-a and PUMA-b. PUMA proteins bind Bcl-2, localize to the mitochondria, and induce cytochrome c release and apoptosis in response to p53. PUMA may be a direct mediator of p53-induced apoptosis.
    Molecular Weight
    20532
    Gene ID
    27113
    NCBI Accession
    NP_001120712, NP_001120713, NP_001120714, NP_055232
    UniProt
    Q9BXH1
    Pathways
    p53 Signaling, Positive Regulation of Endopeptidase Activity
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