STAT3 antibody (pTyr705)

Catalog No. ABIN389665

Product Details anti-STAT3 Antibody

Target: STAT3 (Signal Transducer and Activator of Transcription 3 (Acute-Phase Response Factor) (STAT3))

Binding Specificity: pTyr705

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This STAT3 antibody is un-conjugated

Application: Western Blotting (WB)

Predicted Reactivity: B, M, Pig, Rat

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This STAT3 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding Y705 of human STAT3.

Clone: RB05666

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:500

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Expiry Date: 6 months

References for anti-STAT3 antibody (ABIN389665)

Yu, Zhang, Zhang, Li: "SOCS3 overexpression inhibits advanced glycation end product-induced EMT in proximal tubule epithelial cells." in: Experimental and therapeutic medicine, Vol. 13, Issue 6, pp. 3109-3115, (2017) (PubMed).

Yan, Li, Li, DI, Shen, Zhang, Guo: "Expression of signal transducer and activator of transcription 3 and its phosphorylated form is significantly upregulated in patients with papillary thyroid cancer." in: Experimental and therapeutic medicine, Vol. 9, Issue 6, pp. 2195-2201, (2015) (PubMed).

Yin, Du, Cao, Liu, Xu, Xiang: "Reg3g Promotes Pancreatic Carcinogenesis in a Murine Model of Chronic Pancreatitis." in: Digestive diseases and sciences, (2015) (PubMed).

Zhao, Li, Liao, Luo, Shi, Feng, Chen: "Evodiamine Induces Apoptosis and Inhibits Migration of HCT-116 Human Colorectal Cancer Cells." in: International journal of molecular sciences, Vol. 16, Issue 11, pp. 27411-21, (2015) (PubMed).

Miyachi, Kobayashi, Relja, Fujita, Iwasa, Gabazza, Takei: "Effect of suppressor of cytokine signaling on hepcidin production in hepatitis C virus replicon cells." in: Hepatology research : the official journal of the Japan Society of Hepatology, Vol. 41, Issue 4, pp. 364-74, (2011) (PubMed).

Choi, Lee, Kwak, Kim, Lee, Ye, Kim, Kim, Lee: "Cooperation between integrin alpha5 and tetraspan TM4SF5 regulates VEGF-mediated angiogenic activity." in: Blood, Vol. 113, Issue 8, pp. 1845-55, (2009) (PubMed).

Target Details for STAT3

Target: STAT3 (Signal Transducer and Activator of Transcription 3 (Acute-Phase Response Factor) (STAT3))

Alternative Name: STAT3 (STAT3 Products)

Synonyms: 1110034C02Rik antibody, AW109958 antibody, Aprf antibody, APRF antibody, HIES antibody, Xstat3 antibody, aprf antibody, hies antibody, stat3 antibody, wu:fc15d02 antibody, wu:fl59g06 antibody, z-Stat3 antibody, signal transducer and activator of transcription 3 antibody, signal transduction and activation of transcription 3 antibody, signal transducer and activator of transcription 3, gene 1 L homeolog antibody, signal transducer and activator of transcription 3 (acute-phase response factor) antibody, STAT3 antibody, stat3 antibody, Stat3 antibody, stat3.1.L antibody

Background: STAT3 is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein.

Molecular Weight: 88068

Gene ID: 6774

NCBI Accession: NP_003141, NP_644805, NP_998827

UniProt: P40763

Pathways: JAK-STAT Signaling, RTK Signaling, Interferon-gamma Pathway, Neurotrophin Signaling Pathway, Dopaminergic Neurogenesis, Response to Growth Hormone Stimulus, Carbohydrate Homeostasis, Stem Cell Maintenance, Hepatitis C, Protein targeting to Nucleus, Feeding Behaviour, CXCR4-mediated Signaling Events, Signaling of Hepatocyte Growth Factor Receptor