MUSK antibody (N-Term)

Catalog No. ABIN392019

This anti-MUSK antibody is a Rabbit Polyclonal antibody detecting MUSK in WB, FACS and IHC (p). Suitable for Human. This Primary Antibody has been cited in 2+ publications.

Quick Overview for MUSK antibody (N-Term) (ABIN392019)

Target: MUSK (Muscle, Skeletal, Receptor Tyrosine Kinase (MUSK))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MUSK antibody is un-conjugated

Application: Western Blotting (WB), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: RB01497

Product Details anti-MUSK Antibody

Binding Specificity: AA 35-65, N-Term

Predicted Reactivity: M, Rat

Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogen: This MUSK antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 35-65 amino acids from the N-terminal region of human MUSK.

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000. WB: 1:1000. WB: 1:1000. IHC-P: 1:10~50. FC: 1:10~50

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Expiry Date: 6 months

References for anti-MUSK antibody (ABIN392019)

Chevessier, Faraut, Ravel-Chapuis, Richard, Gaudon, Bauché, Prioleau, Herbst, Goillot, Ioos, Azulay, Attarian, Leroy, Fournier, Legay, Schaeffer, Koenig, Fardeau, Eymard, Pouget, Hantaï: "[Pathophysiological characterization of congenital myasthenic syndromes: the example of mutations in the MUSK gene]." in: Journal de la Société de biologie, Vol. 199, Issue 1, pp. 61-77, (2005) (PubMed).

Chevessier, Faraut, Ravel-Chapuis, Richard, Gaudon, Bauché, Prioleau, Herbst, Goillot, Ioos, Azulay, Attarian, Leroy, Fournier, Legay, Schaeffer, Koenig, Fardeau, Eymard, Pouget, Hantaï: "MUSK, a new target for mutations causing congenital myasthenic syndrome." in: Human molecular genetics, Vol. 13, Issue 24, pp. 3229-40, (2004) (PubMed).

Target Details for MUSK

Target: MUSK (Muscle, Skeletal, Receptor Tyrosine Kinase (MUSK))

Alternative Name: MUSK

Background: Protein kinases are enzymes that transfer a phosphate group from a phosphate donor, generally the g phosphate of ATP, onto an acceptor amino acid in a substrate protein. By this basic mechanism, protein kinases mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation. With more than 500 gene products, the protein kinase family is one of the largest families of proteins in eukaryotes. The family has been classified in 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/threonine (STK) kinase catalytic domains. The tyrosine kinase (TK) group is mainly involved in the regulation of cell-cell interactions such as differentiation, adhesion, motility and death. There are currently about 90 TK genes sequenced, 58 are of receptor protein TK (e.g. EGFR, EPH, FGFR, PDGFR, TRK, and VEGFR families), and 32 of cytosolic TK (e.g. ABL, FAK, JAK, and SRC families).

Molecular Weight: 97056

Gene ID: 4593

NCBI Accession: NP_001159752, NP_001159753, NP_005583

UniProt: O15146

Pathways: RTK Signaling, Regulation of Muscle Cell Differentiation, Synaptic Membrane, Regulation of Cell Size, Skeletal Muscle Fiber Development