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Activin A Receptor Type IB/ALK-4 antibody (AA 134-164)

ACVR1B Reactivity: Human, Mouse WB, FACS Host: Rabbit Polyclonal RB03514 unconjugated
Catalog No. ABIN392232
  • Target See all Activin A Receptor Type IB/ALK-4 (ACVR1B) Antibodies
    Activin A Receptor Type IB/ALK-4 (ACVR1B) (Activin A Receptor, Type IB (ACVR1B))
    Binding Specificity
    • 15
    • 9
    • 6
    • 5
    • 5
    • 4
    • 4
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 134-164
    Reactivity
    • 48
    • 38
    • 28
    • 1
    Human, Mouse
    Host
    • 58
    • 13
    • 3
    • 2
    Rabbit
    Clonality
    • 61
    • 15
    Polyclonal
    Conjugate
    • 34
    • 12
    • 5
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    This Activin A Receptor Type IB/ALK-4 antibody is un-conjugated
    Application
    • 49
    • 36
    • 13
    • 13
    • 13
    • 9
    • 9
    • 6
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB), Flow Cytometry (FACS)
    Predicted Reactivity
    Rat
    Purification
    This antibody is purified through a protein A column, followed by peptide affinity purification.
    Immunogen
    This Activin A Receptor Type IB (ACVR1B) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 134-164 amino acids from the Central region of human Activin A Receptor Type IB (ACVR1B).
    Clone
    RB03514
    Isotype
    Ig Fraction
    Top Product
    Discover our top product ACVR1B Primary Antibody
  • Application Notes
    WB: 1:1000. FC: 1:10~50
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C,-20 °C
    Storage Comment
    Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
    Expiry Date
    6 months
  • Target
    Activin A Receptor Type IB/ALK-4 (ACVR1B) (Activin A Receptor, Type IB (ACVR1B))
    Alternative Name
    Activin A Receptor Type IB (ACVR1B) (ACVR1B Products)
    Synonyms
    ACVR1B antibody, alk4 antibody, skr2 antibody, alk-4 antibody, xalk4 antibody, actrib antibody, acvrlk4 antibody, DKFZp469A1614 antibody, 6820432J04 antibody, ActR-IB antibody, ActRIB antibody, Acvrlk4 antibody, Alk4 antibody, SKR2 antibody, ACTRIB antibody, ACVRLK4 antibody, ALK4 antibody, Skr2 antibody, axis antibody, taram-a antibody, tarama antibody, wu:fb75f01 antibody, activin A receptor type 1B antibody, Activin receptor type-1B antibody, activin A receptor, type IB antibody, activin A receptor, type 1B antibody, activin A receptor type 1Ba antibody, ACVR1B antibody, acvr1b antibody, acv1b antibody, Acvr1b antibody, acvr1ba antibody
    Background
    Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with a cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling, and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. The gene for ACVR1B (activin A type IB receptor) is composed of 11 exons. Alternative splicing and alternative polyadenylation result in 3 fully described transcript variants. The mRNA expression of variants 1, 2, and 3 is confirmed, and a potential fourth variant contains an alternative exon 8 and lacks exons 9 through 11, but its mRNA expression has not been confirmed.
    Molecular Weight
    56807
    Gene ID
    91
    NCBI Accession
    NP_004293, NP_064732, NP_064733
    UniProt
    P36896
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