PTPN3 antibody (AA 366-397)

Catalog No. ABIN392839

Product Details anti-PTPN3 Antibody

Target: PTPN3 (Protein tyrosine Phosphatase, Non-Receptor Type 3 (PTPN3))

Binding Specificity: AA 366-397

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PTPN3 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogen: This PTPH1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 366-397 amino acids from the Central region of human PTPH1.

Clone: RB0626

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000. IHC-P: 1:10~50

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Expiry Date: 6 months

Target Details for PTPN3

Target: PTPN3 (Protein tyrosine Phosphatase, Non-Receptor Type 3 (PTPN3))

Alternative Name: PTPH1 (PTPN3 Products)

Synonyms: PTP-H1 antibody, PTPH1 antibody, 9530011I20Rik antibody, PTPCL antibody, protein tyrosine phosphatase, non-receptor type 3 antibody, PTPN3 antibody, Ptpn3 antibody

Background: Phosphorylation of receptors by protein kinases is a process that can be reversed by a group of enzymes called protein phosphatases. Coordinated control of kinases and phosphatases provides the cell with the capacity to rapidly switch between phosphorylated and dephosphorylated protein states in dynamic response to environmental stimuli. Activation of critical enzymes by kinase phosphorylation alone is not enough to provide adequate regulation ?it is the combination with phosphatase dephosphorylation that effectively creates on/off switches to control cellular events. Errors in control, either through kinases or their counterpart phosphatases, can lead to unchecked cell growth attributable to human cancers and developmental disorders. Potential mechanisms to control dephosphorylation include changes in the expression of protein phosphatases, their subcellular localization, phosphorylation of phosphatase catalytic and regulatory subunits and regulation by endogenous phosphatase inhibitors. Most protein phosphatases are not stringently specific for their substrates. Consequently, changes in phosphatase activity may have a broad impact on dephosphorylation and turnover of phosphoproteins that are substrates for different kinases. This may be an important point of control to connect cellular circuitry of interrelated signaling pathways, and to synchronize physiological responses.

Molecular Weight: 103990

Gene ID: 5774

NCBI Accession: NP_001138840, NP_001138841, NP_001138842, NP_001138843, NP_002820

UniProt: P26045