KCNMB3 antibody (Potassium Large Conductance Calcium-Activated Channel, Subfamily M beta Member 3) (AA 82-182)

Details for Product anti-KCNMB3 Antibody No. ABIN393363, Supplier: Log in to see
Antigen
  • KCNMB3
  • BKBETA3
  • HBETA3
  • KCNMB2
  • KCNMBL
  • SLOBETA3
  • EG435726
  • Gm5707
  • potassium calcium-activated channel subfamily M regulatory beta subunit 3
  • potassium channel subfamily M regulatory beta subunit 3 S homeolog
  • potassium large conductance calcium-activated channel, subfamily M beta member 3
  • potassium large conductance calcium-activated channel, subfamily M, beta member 3
  • KCNMB3
  • kcnmb3.S
  • Kcnmb3
Epitope
AA 82-182
38
23
5
5
5
5
2
2
Reactivity
Human
69
42
42
1
1
Host
Mouse
48
22
Clonality (Clone)
Monoclonal ()
Conjugate
This KCNMB3 antibody is un-conjugated
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
1
1
1
Application
ELISA, Western Blotting (WB)
55
47
39
38
38
18
14
10
1
1
Options
Supplier
Log in to see
Supplier Product No.
Log in to see
Immunogen KCNMB3 (NP_741979, 82 a.a. ~ 182 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 5H1
Isotype IgG2a kappa
Specificity KCNMB3 (NP_741979, 82 a.a. ~ 182 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name KCNMB3 (KCNMB3 Antibody Abstract)
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 31604 DA
Gene ID 12406
NCBI Accession NP_741979
Research Area Neurology, Cell Structure
Application Notes ELISA ~~ 1ug/ml~3ng/ml Western blot ~~ 1:500~1000
Comment

Background: MaxiK channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to the control of smooth muscle tone and neuronal excitability. MaxiK channels can be formed by 2 subunits: the pore-forming alpha subunit and the modulatory beta subunit. The protein encoded by this gene is an auxiliary beta subunit which may partially inactivate or slightly decrease the activation time of MaxiK alpha subunit currents. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 22.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
ELISA image for anti-Potassium Large Conductance Calcium-Activated Channel, Subfamily M beta Member 3 (KCNMB3) (AA 82-182) antibody (ABIN393363) Detection limit for recombinant GST tagged KCNMB3 is approximately 0.3 ng/mL as a cap...
Background publications Lee, Cui: "{beta} subunit-specific modulations of BK channel function by a mutation associated with epilepsy and dyskinesia." in: The Journal of physiology, Vol. 587, Issue Pt 7, pp. 1481-98, 2009 (PubMed).

Zeng, Xia, Lingle: "Species-specific Differences among KCNMB3 BK beta3 auxiliary subunits: some beta3 N-terminal variants may be primate-specific subunits." in: The Journal of general physiology, Vol. 132, Issue 1, pp. 115-29, 2008 (PubMed).

Lorenz, Heils, Kasper, Sander: "Allelic association of a truncation mutation of the KCNMB3 gene with idiopathic generalized epilepsy." in: American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics, Vol. 144B, Issue 1, pp. 10-3, 2006 (PubMed).

Hu, Labuda, Pandolfo, Goss, McDermid, Ali: "Variants of the KCNMB3 regulatory subunit of maxi BK channels affect channel inactivation." in: Physiological genomics, Vol. 15, Issue 3, pp. 191-8, 2003 (PubMed).

Zeng, Xia, Lingle: "Redox-sensitive extracellular gates formed by auxiliary beta subunits of calcium-activated potassium channels." in: Nature structural biology, Vol. 10, Issue 6, pp. 448-54, 2003 (PubMed).

Did you look for something else?