F-Box Protein 6 (FBXO6) (AA 1-294) antibody

Details for Product No. ABIN393713, Supplier: Log in to see
Antigen
  • FBG2
  • FBS2
  • FBX6
  • Fbx6b
  • AA408845
  • Fbs2
  • Fbxo6b
  • Fbg2
  • FBXO6
  • fbg2
  • fbs2
  • fbx6
  • fbx6b
  • fbxo44
  • F-box protein 6
  • F-box protein 6 S homeolog
  • FBXO6
  • Fbxo6
  • fbxo6.S
Epitope
AA 1-294
8
6
6
6
4
2
2
2
1
1
Reactivity
Human
43
8
8
Host
Mouse
25
14
5
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
1
1
1
1
1
1
Application
Immunoprecipitation (IP), Western Blotting (WB)
28
27
9
2
2
Options
Supplier
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Immunogen

Antigen Type: Recombinant Protein

Target/Specificity: FBXO6 (AAH20880.1, 1 a.a. ~ 293 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Clone 3F10
Isotype IgG1 kappa
Specificity FBXO6 (AAH20880, 1 a.a. ~ 294 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Cross-Reactivity (Details) Human: ~~ Positive
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Antigen
Alternative Name FBXO6 (FBXO6 Antibody Abstract)
Background

Other Names: F-box only protein 6, F-box protein that recognizes sugar chains 2, F-box/G-domain protein 2, FBXO6, FBG2, FBS2, FBX6

Gene Description: F-box protein 6

Gene Summary: This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class, and its C-terminal region is highly similar to that of rat NFB42 (neural F Box 42 kDa) which may be involved in the control of the cell cycle. [provided by RefSeq

Molecular Weight 33933 DA
Gene ID 26270
NCBI Accession NP_060908
UniProt Q9NRD1
Application Notes Western blot = 1:500-1000
Comment

Background: This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class, and its C-terminal region is highly similar to that of rat NFB42 (neural F Box 42 kDa) which may be involved in the control of the cell cycle.

Restrictions For Research Use only
Concentration 1 mg/mL
Buffer Clear, colorless solution in phosphate buffered saline,  pH 7.2 .
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-F-Box Protein 6 (FBXO6) (AA 1-294) antibody (ABIN393713) Antibody Reactive Against Recombinant Protein.Western Blot detection against Immunoge...
Western Blotting (WB) image for anti-F-Box Protein 6 (FBXO6) (AA 1-294) antibody (ABIN393713) Western Blot analysis of FBXO6 expression in transfected 293T cell line by FBXO6 mono...
Immunoprecipitation (IP) image for anti-F-Box Protein 6 (FBXO6) (AA 1-294) antibody (ABIN393713) Immunoprecipitation of FBXO6 transfected lysate using anti-FBXO6 monoclonal antibody ...
Background publications Zhang, Brognard, Coughlin, You, Dolled-Filhart, Aslanian, Manning, Abraham, Hunter: "The F box protein Fbx6 regulates Chk1 stability and cellular sensitivity to replication stress." in: Molecular cell, Vol. 35, Issue 4, pp. 442-53, 2009 (PubMed).

Gregory, Barlow, McLay, Kaul, Swarbreck, Dunham, Scott, Howe, Woodfine, Spencer, Jones, Gillson, Searle, Zhou, Kokocinski, McDonald, Evans, Phillips, Atkinson, Cooper, Jones, Hall, Andrews, Lloyd et al.: "The DNA sequence and biological annotation of human chromosome 1. ..." in: Nature, Vol. 441, Issue 7091, pp. 315-21, 2006 (PubMed).

Gerhard, Wagner, Feingold, Shenmen, Grouse, Schuler, Klein, Old, Rasooly, Good, Guyer, Peck, Derge, Lipman, Collins, Jang, Sherry, Feolo, Misquitta, Lee, Rotmistrovsky, Greenhut, Schaefer, Buetow et al.: "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). ..." in: Genome research, Vol. 14, Issue 10B, pp. 2121-7, 2004 (PubMed).

Yoshida, Tokunaga, Chiba, Iwai, Tanaka, Tai: "Fbs2 is a new member of the E3 ubiquitin ligase family that recognizes sugar chains." in: The Journal of biological chemistry, Vol. 278, Issue 44, pp. 43877-84, 2003 (PubMed).

Strausberg, Feingold, Grouse, Derge, Klausner, Collins, Wagner, Shenmen, Schuler, Altschul, Zeeberg, Buetow, Schaefer, Bhat, Hopkins, Jordan, Moore, Max, Wang, Hsieh, Diatchenko, Marusina, Farmer et al.: "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. ..." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 99, Issue 26, pp. 16899-903, 2002 (PubMed).

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