S100A6 antibody (S100 Calcium Binding Protein A6)

Details for Product anti-S100A6 Antibody No. ABIN396706, Supplier: Log in to see
Antigen
  • S100A6
  • 2A9
  • 5B10
  • CABP
  • CACY
  • PRA
  • CALCYCLIN
  • Cacy
  • S100 calcium binding protein A6
  • uncharacterized LOC618256
  • S100 calcium binding protein A6 (calcyclin)
  • S100A6
  • S100a6
  • LOC618256
Reactivity
Human
143
65
52
10
4
4
4
4
1
Host
Mouse
105
57
9
3
3
2
1
Clonality (Clone)
Monoclonal ()
Conjugate
This S100A6 antibody is un-conjugated
18
12
5
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Application
ELISA, Western Blotting (WB)
145
92
85
42
24
19
13
12
9
9
5
3
1
1
Options
Supplier
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Immunogen

Antigen Type: Recombinant Protein

Target/Specificity: S100A6 (NP_055439, 18 a.a. ~ 90 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Clone 6D1
Isotype IgG2a kappa
Specificity S100A6 (NP_055439, 18 a.a. ~ 91 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Cross-Reactivity (Details) Human: ~~ Positive
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Plasmids, Primers & others Plasmids, Primers & others S100A6 products on genomics-online (e.g. as negative or positive controls)
Antigen S100 Calcium Binding Protein A6 (S100A6)
Alternative Name S100A6 (S100A6 Antibody Abstract)
Background

Other Names: Protein S100-A6, Calcyclin, Growth factor-inducible protein 2A9, MLN 4, Prolactin receptor-associated protein, PRA, S100 calcium-binding protein A6, S100A6, CACY

Gene Description: S100 calcium binding protein A6

Gene Summary: The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in stimulation of Ca2+-dependent insulin release, stimulation of prolactin secretion, and exocytosis. Chromosomal rearrangements and altered expression of this gene have been implicated in melanoma. [provided by RefSeq

Molecular Weight 10180 DA
Gene ID 6277
NCBI Accession NP_055439
UniProt P06703
Application Notes Western blot = 1:500-1000
Comment

Background: The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in stimulation of Ca2+-dependent insulin release, stimulation of prolactin secretion, and exocytosis. Chromosomal rearrangements and altered expression of this gene have been implicated in melanoma.

Restrictions For Research Use only
Buffer Clear, colorless solution in phosphate buffered saline,  pH 7.2 .
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-S100 Calcium Binding Protein A6 (S100A6) antibody (ABIN396706) Western Blot analysis of S100A6 expression in transfected 293T cell line by S100A6 mo...
Immunohistochemistry (IHC) image for anti-S100 Calcium Binding Protein A6 (S100A6) antibody (ABIN396706) anti-S100 Calcium Binding Protein A6 (S100A6) antibody (Image 2)
Western Blotting (WB) image for anti-S100 Calcium Binding Protein A6 (S100A6) antibody (ABIN396706) Antibody Reactive Against Recombinant Protein.Western Blot detection against Immunoge...
Western Blotting (WB) image for anti-S100 Calcium Binding Protein A6 (S100A6) antibody (ABIN396706) S100A6 monoclonal antibody (M16), clone 6D1 Western Blot analysis of S100A6 expressio...
ELISA image for anti-S100 Calcium Binding Protein A6 (S100A6) antibody (ABIN396706) Detection limit for recombinant GST tagged S100A6 is approximately 0.03ng/ml as a cap...
Background publications van Dieck, Lum, Teufel, Fersht: "S100 proteins interact with the N-terminal domain of MDM2." in: FEBS letters, Vol. 584, Issue 15, pp. 3269-74, 2010 (PubMed).

Wei, Hoover, Ross, Zhou, Meani, Edwards, Spehalski, Risinger, Alvord, Quiñones, Belluco, Martella, Campagnutta, Ravaggi, Dai, Goldsmith, Woolard, Pecorelli, Liotta, Petricoin, Simpson: "Serum S100A6 concentration predicts peritoneal tumor burden in mice with epithelial ovarian cancer and is associated with advanced stage in patients." in: PLoS ONE, Vol. 4, Issue 10, pp. e7670, 2009 (PubMed).

Zimmermann, Biniossek, Maurer, Münzer, Pantic, Veelken, Martens: "Proteomic profiling in distinct cellular compartments of tumor cells reveals p53-dependent upregulation of S100A6 upon induction of telomere dysfunction." in: Proteomics, Vol. 9, Issue 22, pp. 5175-87, 2009 (PubMed).

Nedjadi, Kitteringham, Campbell, Jenkins, Park, Navarro, Ashcroft, Tepikin, Neoptolemos, Costello: "S100A6 binds to annexin 2 in pancreatic cancer cells and promotes pancreatic cancer cell motility." in: British journal of cancer, Vol. 101, Issue 7, pp. 1145-54, 2009 (PubMed).

Ishii, Suzuki, Satomi, Kobayashi, Sakashita, Kano, Pei, Minami, Ishikawa, Noguchi: "Increased cytoplasmic S100A6 expression is associated with pulmonary adenocarcinoma progression." in: Pathology international, Vol. 59, Issue 9, pp. 623-30, 2009 (PubMed).

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