NFKBIA antibody (Nuclear Factor of kappa Light Polypeptide Gene Enhancer in B-Cells Inhibitor, alpha) (AA 32-291) (Biotin)

Details for Product anti-NFKBIA Antibody No. ABIN4224345
Antigen
Epitope
AA 32-291
64
54
40
35
35
18
17
15
15
12
10
10
8
7
7
5
5
4
4
3
3
3
3
3
3
3
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human, Mouse (Murine), Rat (Rattus)
478
301
244
31
24
20
19
9
2
2
2
1
1
Host
Mouse
422
61
7
7
Clonality (Clone)
Monoclonal ()
Conjugate
This NFKBIA antibody is conjugated to Biotin
27
13
13
13
13
13
13
12
10
6
6
6
3
3
3
3
3
Application
ELISA
357
183
156
78
76
60
41
28
19
18
14
4
4
3
3
3
1
1
1
Options
Immunogen A recombinant protein corresponding to amino acid residues 32-291 of human IkBa was used as immunogen.
Clone 6A920
Isotype IgG1 kappa
Specificity A 40 kDa band is observed.
Purification Protein G purified
Antigen
Alternative Name IkB-alpha (NFKBIA Antibody Abstract)
Background Gene Symbol: NFKBIA
Gene ID 4792
Pathways NF-kappaB Signaling, TCR Signaling, TLR Signaling, Fc-epsilon Receptor Signaling Pathway, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Maintenance of Protein Location, Hepatitis C, Protein targeting to Nucleus, Toll-Like Receptors Cascades
Application Notes ELISA 1:100-1:2000
Comment

The antibodies are intended for use in vitro experiments only. Our antibodies have not been tested nor are recommended for use in vivo.

Restrictions For Research Use only
Format Liquid
Buffer PBS
Buffer contains: 0.05 % Sodium Azide
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Storage Comment Store at 4°C. Do not freeze.
Product cited in: Delhase, Kim, Lee, Naiki-Ito, Chen, Ahn, Murata, Kim, Lautsch, Kobayashi, Shirai, Karin, Nakanishi: "TANK-binding kinase 1 (TBK1) controls cell survival through PAI-2/serpinB2 and transglutaminase 2." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 109, Issue 4, pp. E177-86, 2012 (PubMed).

Pejanovic, Hochrainer, Liu, Aerne, Soares, Anrather: "Regulation of nuclear factor κB (NF-κB) transcriptional activity via p65 acetylation by the chaperonin containing TCP1 (CCT)." in: PLoS ONE, Vol. 7, Issue 7, pp. e42020, 2012 (PubMed).

Harikumar, Sung, Pandey, Guha, Krishnan, Aggarwal: "Escin, a pentacyclic triterpene, chemosensitizes human tumor cells through inhibition of nuclear factor-kappaB signaling pathway." in: Molecular pharmacology, Vol. 77, Issue 5, pp. 818-27, 2010 (PubMed).

Saccani, Marazzi, Beg, Natoli: "Degradation of promoter-bound p65/RelA is essential for the prompt termination of the nuclear factor kappaB response." in: The Journal of experimental medicine, Vol. 200, Issue 1, pp. 107-13, 2004 (PubMed).

Xia, Ye, Li, Wang, He, Lin, Yao, Ma, Slungaard, Hebbel, Key, Geng: "Andrographolide attenuates inflammation by inhibition of NF-kappa B activation through covalent modification of reduced cysteine 62 of p50." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 173, Issue 6, pp. 4207-17, 2004 (PubMed).

Han, Karabiyikoglu, Kelly, Sobel, Yenari: "Mild hypothermia inhibits nuclear factor-kappaB translocation in experimental stroke." in: Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, Vol. 23, Issue 5, pp. 589-98, 2003 (PubMed).

Saccani, Pantano, Natoli: "Modulation of NF-kappaB activity by exchange of dimers." in: Molecular cell, Vol. 11, Issue 6, pp. 1563-74, 2003 (PubMed).

Ikezoe, Yang, Heber, Taguchi, Koeffler: "PC-SPES: a potent inhibitor of nuclear factor-kappa B rescues mice from lipopolysaccharide-induced septic shock." in: Molecular pharmacology, Vol. 64, Issue 6, pp. 1521-9, 2003 (PubMed).

Saccani, Pantano, Natoli: "Two waves of nuclear factor kappaB recruitment to target promoters." in: The Journal of experimental medicine, Vol. 193, Issue 12, pp. 1351-9, 2001 (PubMed).

Saccani, Pantano, Natoli: "p38-Dependent marking of inflammatory genes for increased NF-kappa B recruitment." in: Nature immunology, Vol. 3, Issue 1, pp. 69-75, 2001 (PubMed).