Caspase 9 antibody (Caspase 9, Apoptosis-Related Cysteine Peptidase)

Details for Product anti-CASP9 Antibody No. ABIN4288194, Supplier: Log in to see
Antigen
  • CASP9
  • AI115399
  • APAF-3
  • AW493809
  • CASP-9
  • Caspase-9
  • ICE-LAP6
  • Mch6
  • Apaf3
  • Casp-9-CTD
  • Casp9_v1
  • Ice-Lap6
  • APAF3
  • MCH6
  • PPP1R56
  • caspase 9
  • CASP9
  • Casp9
Reactivity
Dog (Canine), Gerbil, Human, Mouse (Murine), Rat (Rattus)
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143
132
22
11
8
5
5
4
4
3
1
Host
Rabbit
419
47
Clonality
Polyclonal
Conjugate
This Caspase 9 antibody is un-conjugated
10
10
7
4
4
4
4
4
4
4
4
4
4
4
4
3
3
Application
Flow Cytometry (FACS), Immunohistochemistry (IHC), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunoprecipitation (IP)
404
151
137
89
75
66
53
32
23
15
13
9
6
2
2
2
1
Options
Supplier
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Supplier Product No.
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Immunogen Human Caspase 9 recombinant protein catalytic subunits (NP_001220).
Specificity This antibody detects both the pro- and active-Caspase 9 forms. In western blots, the proform of caspase-9 is detected at ~50 kDa, the large subunit at ~35 kDa, and the small subunit at ~15 kDa. Intermediate caspase-9 cleavage forms may also be seen at ~21 kDa.
Purification Unpurified
Alternative Name Caspase-9 (CASP9 Antibody Abstract)
Background Gene Symbol: CASP9
Gene ID 842
UniProt P55211
Pathways MAPK Signaling, RTK Signaling, Apoptosis, Caspase Cascade in Apoptosis, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Positive Regulation of Endopeptidase Activity
Application Notes Immunohistochemistry, Immunoprecipitation 1:50-1:200, Immunohistochemistry-Paraffin 1:1000-1:5000, Immunohistochemistry-Frozen Assay Dependent, Flow (Intracellular)Caspase-9 immunostaining may appear diffuse or punctate. It may be localized in the cytosol, mitochondria, and nucleus. Caspase-9 staining in the nucleus is considered to be an indication of active Caspase-9. Both pro and active/cleaved Caspase-9 staining may also be seen in the mitochondria. 2. Caspase antibodies are classical tools for detecting inactive (pro) and active (cleaved) forms of the enzymes. The presence of the large or small subunits in western blots is considered to be a marker of caspase activation. Use of this antibody in Flow-Intracellular reported in scientific literature (PMID 24804954)
Comment

The antibodies are intended for use in vitro experiments only. Our antibodies have not been tested nor are recommended for use in vivo.

Restrictions For Research Use only
Format Liquid
Buffer Whole antisera
Buffer contains: 0.05 % Sodium Azide
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C,-20 °C
Storage Comment Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Supplier Images
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) image for anti-Caspase 9, Apoptosis-Related Cysteine Peptidase (CASP9) antibody (ABIN4288194) Immunohistochemistry-Paraffin: Caspase-9 Antibody [ABIN42881948] - Analysis Human Bra...
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) image for anti-Caspase 9, Apoptosis-Related Cysteine Peptidase (CASP9) antibody (ABIN4288194) Immunohistochemistry-Paraffin: Caspase-9 Antibody [ABIN42881948] - Analysis of Dog Br...
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) image for anti-Caspase 9, Apoptosis-Related Cysteine Peptidase (CASP9) antibody (ABIN4288194) Immunohistochemistry-Paraffin: Caspase-9 Antibody [ABIN42881948] - Analysis of Dog Br...
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) image for anti-Caspase 9, Apoptosis-Related Cysteine Peptidase (CASP9) antibody (ABIN4288194) Immunohistochemistry-Paraffin: Caspase-9 Antibody [ABIN42881948] - Analysis of Capase...
Product cited in: Sundberg, Silva, King, Pratt: "Skin Diseases in Laboratory Mice: Approaches to Drug Target Identification and Efficacy Screening." in: Methods in molecular biology (Clifton, N.J.), Vol. 1438, pp. 199-224, 2016 (PubMed). (Sample species: Mouse (Murine)). Further details: Immunohistochemistry

Kato, Kato, Kusano, Nishino et al.: "New Strategy That Delays Progression of Amyotrophic Lateral Sclerosis in G1H-G93A Transgenic Mice: Oral Administration of Xanthine Oxidoreductase Inhibitors That Are Not Substrates for the Purine ..." in: Journal of neuropathology and experimental neurology, 2016 (PubMed). (Sample species: Rat (Rattus)).

Erdoğan, Tunçdemir, Kelten, Akdemir, Karaoğlan, Taşdemiroğlu: "The Effects of Difumarate Salt S-15176 after Spinal Cord Injury in Rats." in: Journal of Korean Neurosurgical Society, Vol. 57, Issue 6, pp. 445-54, 2015 (PubMed). (Sample species: Rat (Rattus)). Further details: Immunohistochemistry (Paraffin-embedded Sections)

Ichihara, Wang, Jinnin, Izuno, Shimozono, Yamane, Fujisawa, Moriya, Fukushima, Inoue, Ihn: "Upregulation of miR-18a-5p contributes to epidermal necrolysis in severe drug eruptions." in: The Journal of allergy and clinical immunology, Vol. 133, Issue 4, pp. 1065-74, 2014 (PubMed). (Sample species: Human). Further details: Western Blotting

Potter, Wang, Silva, Kennedy, Stearns, Burzenski, Shultz, Hogenesch, Sundberg: "Chronic proliferative dermatitis in Sharpin null mice: development of an autoinflammatory disease in the absence of B and T lymphocytes and IL4/IL13 signaling." in: PLoS ONE, Vol. 9, Issue 1, pp. e85666, 2014 (PubMed). (Sample species: Mouse (Murine)). Further details: Immunohistochemistry (Paraffin-embedded Sections)

Pradhan, Pratheek, Garai, Kumar, Meena, Ghosh, Singh, Kumari, Chandrashekar, Goswami, Chattopadhyay, Kar, Maiti: "Induction of apoptosis by Fe(salen)Cl through caspase-dependent pathway specifically in tumor cells." in: Cell biology international, Vol. 38, Issue 10, pp. 1118-31, 2014 (PubMed). (Sample species: Human). Further details: Flow Cytometry,Immunochromatography

Topcu, Vatansever, Bayram, Var, Cetin, Civi: "The effects of lornoxicam on neuroprotection following diffuse traumatic brain injury in rats." in: Turkish neurosurgery, Vol. 23, Issue 6, pp. 764-71, 2013 (PubMed). (Sample species: Rat (Rattus)). Further details: Immunohistochemistry (Paraffin-embedded Sections)

Herold, Rennekampff, Ohm, Strauss, Linkner, Reimers, Allmeling, Vaske, Vogt: "Apoptosis in extracorporeal preserved inguinal fat flaps of the rat." in: Apoptosis : an international journal on programmed cell death, Vol. 17, Issue 4, pp. 400-9, 2012 (PubMed). (Sample species: Rat (Rattus)). Further details: Immunocytochemistry,Immunofluorescence,Immunohistochemistry

Zhang, Chen, De Paiva, Corrales, Volpe, McClellan, Farley, Li, Pflugfelder: "Interferon-? exacerbates dry eye-induced apoptosis in conjunctiva through dual apoptotic pathways." in: Investigative ophthalmology & visual science, Vol. 52, Issue 9, pp. 6279-85, 2011 (PubMed).

Price, Yang, Karlnoski, Kumar, Chaparro, Camporesi: "Effect of continuous infusion of asialoerythropoietin on short-term changes in infarct volume, penumbra apoptosis and behaviour following middle cerebral artery occlusion in rats." in: Clinical and experimental pharmacology & physiology, Vol. 37, Issue 2, pp. 185-92, 2010 (PubMed).

Liu, Keeler, Zhukareva, Houlé: "Cycling exercise affects the expression of apoptosis-associated microRNAs after spinal cord injury in rats." in: Experimental neurology, Vol. 226, Issue 1, pp. 200-6, 2010 (PubMed).

Hermel, Gafni, Propp, Leavitt, Wellington, Young, Hackam, Logvinova, Peel, Chen, Hook, Singaraja, Krajewski, Goldsmith, Ellerby, Hayden, Bredesen, Ellerby: "Specific caspase interactions and amplification are involved in selective neuronal vulnerability in Huntington's disease." in: Cell death and differentiation, Vol. 11, Issue 4, pp. 424-38, 2004 (PubMed). Further details: Immunohistochemistry (Paraffin-embedded Sections)

Krajewska, Rosenthal, Mikolajczyk, Stennicke, Wiesenthal, Mai, Naito, Salvesen, Reed, Fiskum, Krajewski: "Early processing of Bid and caspase-6, -8, -10, -14 in the canine brain during cardiac arrest and resuscitation." in: Experimental neurology, Vol. 189, Issue 2, pp. 261-79, 2004 (PubMed). Further details: Western Blotting

Cowan, Thai, Krajewski, Reed, Nicholson, Kaufmann, Roskams: "Caspases 3 and 9 send a pro-apoptotic signal from synapse to cell body in olfactory receptor neurons." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 21, Issue 18, pp. 7099-109, 2001 (PubMed).

Krajewski, Krajewska, Ellerby, Welsh, Xie, Deveraux, Salvesen, Bredesen, Rosenthal, Fiskum, Reed: "Release of caspase-9 from mitochondria during neuronal apoptosis and cerebral ischemia." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 96, Issue 10, pp. 5752-7, 1999 (PubMed). (Sample species: Human). Further details: Western Blotting

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