TLR3 antibody (Toll-Like Receptor 3) (pTyr759)

Details for Product anti-TLR3 Antibody No. ABIN4360085
Antigen
  • CD283
  • IIAE2
  • AI957183
  • zgc:123006
  • toll like receptor 3
  • toll-like receptor 3
  • TLR3
  • Tlr3
  • tlr3
Alternatives
anti-Dog (Canine) TLR3 antibody for Immunohistochemistry (Frozen Sections)
Epitope
pTyr759
28
26
15
10
7
7
5
5
5
5
4
4
4
4
3
3
3
3
2
2
2
2
2
1
1
1
1
1
1
1
Reactivity
Human, Mouse (Murine)
211
149
58
8
3
2
2
1
1
1
1
1
1
Host
Rabbit
200
74
9
2
2
Clonality
Polyclonal
Conjugate
This TLR3 antibody is un-conjugated
30
28
17
9
8
6
3
3
3
3
3
3
1
1
1
1
1
Application
Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (Frozen Sections) (IHC (fro)), Western Blotting (WB)
184
88
86
67
31
28
25
20
13
12
10
7
5
4
1
1
Options
Immunogen A portion of amino acids 750-800, containing a phosphorylated tyrosine residue at position 759, of human TLR3 was used as the immunogen.
Purification Immunogen affinity purified
Plasmids, Primers & others Plasmids, Primers & others TLR3 products on genomics-online (e.g. as negative or positive controls)
Antigen
Alternative Name TLR3 (TLR3 Antibody Abstract)
Background Gene Symbol: TLR3
Gene ID 7098
Pathways TLR Signaling, Activation of Innate immune Response, Hepatitis C, Toll-Like Receptors Cascades
Application Notes Western Blot 0.1-1.0 μg/mL, Immunocytochemistry/Immunofluorescence 1:10-1:2000, Immunohistochemistry-Frozen 1:10-1:2000Additional western blot data can be found in the publication section. See PMIDs: 19359485, 21988875, and 24526685.
Comment

The antibodies are intended for use in vitro experiments only. Our antibodies have not been tested nor are recommended for use in vivo.

Restrictions For Research Use only
Format Liquid
Concentration 0.2 mg/mL
Buffer 0.1 mL PBS and 0.05 % BSA
Buffer contains: 0.05 % Sodium Azide
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C,-20 °C
Storage Comment Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Product cited in: Zhang, Xiang, Wang, Yan, Zhu, Guo, Sengupta, Chen, Loughran, Lu, Wang, Billiar et al.: "Interferon β (IFN-β) Production during the Double-stranded RNA (dsRNA) Response in Hepatocytes Involves Coordinated and Feedforward Signaling through Toll-like Receptor 3 (TLR3), RNA-dependent ..." in: The Journal of biological chemistry, Vol. 291, Issue 29, pp. 15093-107, 2016 (PubMed). (Sample species: Mouse (Murine)). Further details: Immunocytochemistry,Western Blotting,Immunofluorescence

Nakama, Yoshida, Ishikawa, Kobayashi, Zhou, Nakao, Sassa, Oshima, Takao, Shimahara, Yoshikawa, Hamasaki, Ohgi, Hayashi, Matsuda, Kudo, Nozaki, Ogura, Kuroda, Ishibashi: "Inhibition of choroidal fibrovascular membrane formation by new class of RNA interference therapeutic agent targeting periostin." in: Gene therapy, Vol. 22, Issue 2, pp. 127-37, 2015 (PubMed). Further details: Western Blotting

Takanashi, Sudo, Ueda, Ohno, Yamada, Osakabe, Goto, Matsunaga, Ishikawa, Usui, Kuroda: "Novel Types of Small RNA Exhibit Sequence- and Target-dependent Angiogenesis Suppression Without Activation of Toll-like Receptor 3 in an Age-related Macular Degeneration (AMD) Mouse Model." in: Molecular therapy. Nucleic acids, Vol. 4, pp. e258, 2015 (PubMed). Method employed by authors: Western Blotting (WB) (Sample species: Mouse (Murine)).

Hsieh, Chang, Chen, Li, Chuang, Yu, Cheung, Chen, Maa, Leu: "The inducible nitric-oxide synthase (iNOS)/Src axis mediates Toll-like receptor 3 tyrosine 759 phosphorylation and enhances its signal transduction, leading to interferon-β synthesis in macrophages." in: The Journal of biological chemistry, Vol. 289, Issue 13, pp. 9208-20, 2014 (PubMed). Further details: Western Blotting

Kleinman, Kaneko, Cho, Dridi, Fowler, Blandford, Albuquerque, Hirano, Terasaki, Kondo, Fujita, Ambati, Tarallo, Gelfand, Bogdanovich, Baffi, Ambati: "Short-interfering RNAs induce retinal degeneration via TLR3 and IRF3." in: Molecular therapy : the journal of the American Society of Gene Therapy, Vol. 20, Issue 1, pp. 101-8, 2012 (PubMed).

Cho, Albuquerque, Kleinman, Tarallo, Greco, Nozaki, Green, Baffi, Ambati, De Falco, Alexander, Brunetti, De Falco, Ambati: "Small interfering RNA-induced TLR3 activation inhibits blood and lymphatic vessel growth." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 106, Issue 17, pp. 7137-42, 2009 (PubMed). (Sample species: Mouse (Murine)). Further details: Western Blotting

Xu, Santini, Matthews, Chiu, Plebani, He, Chen, Cerutti: "Viral double-stranded RNA triggers Ig class switching by activating upper respiratory mucosa B cells through an innate TLR3 pathway involving BAFF." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 181, Issue 1, pp. 276-87, 2008 (PubMed). Further details: Immunocytochemistry,Immunofluorescence

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