Product cited in:
Wang, Ren, Liu, Lahat, Torres, Lopez, Lazar, Hayes-Jordan, Liu, Bankson, Hazle, Lev: "TRAIL and doxorubicin combination induces proapoptotic and antiangiogenic effects in soft tissue sarcoma in vivo." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 16, Issue 9, pp. 2591-604, 2010 (PubMed).
(Sample species: Human). Further details: Immunohistochemistry (Paraffin-embedded Sections)
Abdelrahim, Newman, Vanderlaag, Samudio, Safe: "3,3'-diindolylmethane (DIM) and its derivatives induce apoptosis in pancreatic cancer cells through endoplasmic reticulum stress-dependent upregulation of DR5." in: Carcinogenesis, Vol. 27, Issue 4, pp. 717-28, 2006 (PubMed).
Further details: Western Blotting
Younes, Georgakis, Rahmani, Beer, Younes: "Functional expression of TRAIL receptors TRAIL-R1 and TRAIL-R2 in esophageal adenocarcinoma." in: European journal of cancer (Oxford, England : 1990), Vol. 42, Issue 4, pp. 542-7, 2006 (PubMed).
Further details: Western Blotting,Immunohistochemistry (Paraffin-embedded Sections),Cell Sorting
Georgakis, Li, Humphreys, Andreeff, OBrien, Younes, Carbone, Albert, Younes et al.: "Activity of selective fully human agonistic antibodies to the TRAIL death receptors TRAIL-R1 and TRAIL-R2 in primary and cultured lymphoma cells: induction of apoptosis and enhancement of ..." in: British journal of haematology, Vol. 130, Issue 4, pp. 501-10, 2005 (PubMed).
Further details: Immunocytochemistry,Immunofluorescence
Kim, Nakagawa, Fei, Rustgi, El-Deiry: "Targeting Bcl-xL in esophageal squamous cancer to sensitize to chemotherapy plus TRAIL-induced apoptosis while normal epithelial cells are protected by blockade of caspase 9." in: Cell death and differentiation, Vol. 11, Issue 5, pp. 583-7, 2004 (PubMed).
Dandrea, Hellmold, Jonsson, Zhivotovsky, Hofer, Wärngård, Cotgreave: "The transcriptosomal response of human A549 lung cells to a hydrogen peroxide-generating system: relationship to DNA damage, cell cycle arrest, and caspase activation." in: Free radical biology & medicine, Vol. 36, Issue 7, pp. 881-96, 2004 (PubMed).
Jin, McDonald, Dicker, El-Deiry: "Deficient tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) death receptor transport to the cell surface in human colon cancer cells selected for resistance to TRAIL-induced apoptosis." in: The Journal of biological chemistry, Vol. 279, Issue 34, pp. 35829-39, 2004 (PubMed).
Fan, Zou, Song, Wei: "Synergistic antitumor activity of TRAIL combined with chemotherapeutic agents in A549 cell lines in vitro and in vivo." in: Cancer chemotherapy and pharmacology, Vol. 55, Issue 2, pp. 189-96, 2004 (PubMed).
Zou, Liu, Yue, Zhou, Sporn, Lotan, Khuri, Sun et al.: "c-Jun NH2-terminal kinase-mediated up-regulation of death receptor 5 contributes to induction of apoptosis by the novel synthetic triterpenoid methyl-2-cyano-3,12-dioxooleana-1, 9-dien-28-oate in ..." in: Cancer research, Vol. 64, Issue 20, pp. 7570-8, 2004 (PubMed).
Kandasamy, Srinivasula, Alnemri, Thompson, Korsmeyer, Bryant, Srivastava et al.: "Involvement of proapoptotic molecules Bax and Bak in tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced mitochondrial disruption and apoptosis: differential regulation of ..." in: Cancer research, Vol. 63, Issue 7, pp. 1712-21, 2003 (PubMed).
Koyama et al.: "Flow cytometric measurement of tumor necrosis factor-related apoptosis-inducing ligand and its receptors in gastric epithelium and infiltrating mucosal lymphocytes in Helicobacter pylori-associated ..." in: Journal of gastroenterology and hepatology, Vol. 18, Issue 7, pp. 763-70, 2003 (PubMed).
Further details: Flow Cytometry
Koyama, Koike, Adachi: "Expression of TNF-related apoptosis-inducing ligand (TRAIL) and its receptors in gastric carcinoma and tumor-infiltrating lymphocytes: a possible mechanism of immune evasion of the tumor." in: Journal of cancer research and clinical oncology, Vol. 128, Issue 2, pp. 73-9, 2002 (PubMed).
Zhang, Xie, Xu, Yang, Xu, Sun, Wang, Curiel, Hsu, Mountz: "Hepatic DR5 induces apoptosis and limits adenovirus gene therapy product expression in the liver." in: Journal of virology, Vol. 76, Issue 11, pp. 5692-700, 2002 (PubMed).
Eid, Lewis, Kumar: "Mifepristone pretreatment overcomes resistance of prostate cancer cells to tumor necrosis factor alpha-related apoptosis-inducing ligand (TRAIL)." in: Molecular cancer therapeutics, Vol. 1, Issue 10, pp. 831-40, 2002 (PubMed).
Cuello, Ettenberg, Clark, Keane, Posner, Nau, Dennis, Lipkowitz et al.: "Down-regulation of the erbB-2 receptor by trastuzumab (herceptin) enhances tumor necrosis factor-related apoptosis-inducing ligand-mediated apoptosis in breast and ovarian cancer cell lines that ..." in: Cancer research, Vol. 61, Issue 12, pp. 4892-900, 2001 (PubMed).
Basile, Zacny, Münger et al.: "The cytokines tumor necrosis factor-alpha (TNF-alpha ) and TNF-related apoptosis-inducing ligand differentially modulate proliferation and apoptotic pathways in human keratinocytes expressing the ..." in: The Journal of biological chemistry, Vol. 276, Issue 25, pp. 22522-8, 2001 (PubMed).
Burns, Bernhard, El-Deiry: "Tissue specific expression of p53 target genes suggests a key role for KILLER/DR5 in p53-dependent apoptosis in vivo." in: Oncogene, Vol. 20, Issue 34, pp. 4601-12, 2001 (PubMed).
Kim, Fisher, Xu, el-Deiry: "Molecular determinants of response to TRAIL in killing of normal and cancer cells." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 6, Issue 2, pp. 335-46, 2000 (PubMed).