CD74 antibody (HLA-DR-gamma)

Details for Product anti-CD74 Antibody No. ABIN439017
Target
Reactivity
Human
296
85
27
22
Host
Mouse
242
76
2
2
Clonality (Clone)
Monoclonal ()
Conjugate
This CD74 antibody is un-conjugated
22
18
12
10
9
7
5
5
5
5
5
5
5
5
5
5
5
5
5
4
4
4
4
4
4
4
4
4
4
4
4
4
4
4
4
4
3
3
3
3
3
3
1
1
1
1
1
1
1
1
1
Application
Flow Cytometry (FACS), Immunoprecipitation (IP)
182
165
159
77
55
48
46
40
38
25
13
9
4
2
2
2
1
1
1
1
Options
Immunogen Synthetic peptide derived from the sequence of human CLIP
Clone CerCLIP-1
Isotype IgG1
Purification Protein G purified
Target
Alternative Name CD74 (CD74 Antibody Abstract)
Background Gene Symbol: CD74
Gene ID 972
Pathways Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Negative Regulation of intrinsic apoptotic Signaling, Cancer Immune Checkpoints
Application Notes Flow Cytometry 2 μg/mL, Immunoprecipitation 1:10-1:500
Comment

The antibodies are intended for use in vitro experiments only. Our antibodies have not been tested nor are recommended for use in vivo.

Restrictions For Research Use only
Format Liquid
Buffer PBS
Buffer contains: 0.9 % Sodium Azide
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid freeze-thaw cycles
Storage -20 °C
Storage Comment Store at -20°C. Avoid freeze-thaw cycles.
Images
Image no. 1 for anti-HLA-DR-gamma (CD74) antibody (ABIN439017) Flow Cytometry: CD74 Antibody (CerCLIP.1) - A cell surface stain was performed on Da...
Product cited in: Ladowski, Martens, Reyes, Hauptfeld-Dolejsek, Tector, Tector: "Examining epitope mutagenesis as a strategy to reduce and eliminate human antibody binding to class II swine leukocyte antigens." in: Immunogenetics, Vol. 71, Issue 7, pp. 479-487, 2019 (PubMed). Method employed by authors: Flow Cytometry (FACS)

Ladowski, Martens, Reyes, Wang, Eckhoff, Hauptfeld-Dolejsek, Tector, Tector: "Examining the Biosynthesis and Xenoantigenicity of Class II Swine Leukocyte Antigen Proteins." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 200, Issue 8, pp. 2957-2964, 2018 (PubMed).

Denzin, Hammond, Cresswell: "HLA-DM interactions with intermediates in HLA-DR maturation and a role for HLA-DM in stabilizing empty HLA-DR molecules." in: The Journal of experimental medicine, Vol. 184, Issue 6, pp. 2153-65, 1997 (PubMed).

Denzin, Robbins, Carboy-Newcomb, Cresswell: "Assembly and intracellular transport of HLA-DM and correction of the class II antigen-processing defect in T2 cells." in: Immunity, Vol. 1, Issue 7, pp. 595-606, 1995 (PubMed).

Denzin, Cresswell: "HLA-DM induces CLIP dissociation from MHC class II alpha beta dimers and facilitates peptide loading." in: Cell, Vol. 82, Issue 1, pp. 155-65, 1995 (PubMed).