GGCX antibody (C-Term)

Catalog No. ABIN452673

Product Details anti-GGCX Antibody

Target: GGCX (gamma-Glutamyl Carboxylase (GGCX))

Binding Specificity: C-Term

Reactivity: Human, Dog

Host: Goat

Clonality: Polyclonal

Conjugate: This GGCX antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Specificity: GGCX antibody AP09596PU-N is expected to recognize both isoforms (NP_000812.2 and NP_001135741.1).

Cross-Reactivity (Details): Species reactivity (expected):Canine (Dog).
Species reactivity (tested):Human.

Purification: Ammonium Sulphate Precipitation followed by antigen Affinity Chromatography using the immunizing peptide.

Immunogen: Peptide with sequence C-PPESNPDPVHSE, from the C-Terminus of the protein sequence according to NP_000812.2 and NP_001135741.1.

Application Details

Application Notes: Peptide ELISA: GGCX Antibody Detection limit dilution 1/32000. Western blot: 0.3-1 μg/mL. Approx 85 kDa band observed in Human Muscle lysates(calculated MW of 85 kDa according to NP_000812.2).
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 0.5 mg/mL

Buffer: Tris saline, pH 7.3 containing 0.02 % Sodium Azide as preservative and 0.5 % BSA as stabilizer.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.

Target Details for GGCX

Target: GGCX (gamma-Glutamyl Carboxylase (GGCX))

Alternative Name: GGCX (GGCX Products)

Synonyms: GGCX antibody, cb751 antibody, si:ch1073-230p18.3 antibody, zgc:158736 antibody, ggcx antibody, GGC antibody, vkcfd1 antibody, CG13927 antibody, DgammaC antibody, Dmel\\CG13927 antibody, dGC antibody, dgammaC antibody, gammaC antibody, VKCFD1 antibody, gamma-glutamyl carboxylase antibody, gamma-glutamyl carboxylase L homeolog antibody, GGCX antibody, ggcx antibody, GC antibody, sce5891 antibody, ggcx.L antibody, Ggcx antibody

Background: Gamma-glutamyl carboxylase GGCX is an enzyme which catalyzes the posttranslational modification of vitamin K-dependent protein. Many of these vitamin K-dependent proteins are involved in coagulation so the function of the encoded enzyme is essential for hemostasis. Mutations in this gene are associated with vitamin K-dependent coagulation defect and PXE-like disorder with multiple coagulation factor deficiency. GGCX accomplishes the posttranslational modification required for the activity of all of the vitamin K-dependent proteins (Wu et al., 1991 [PubMed 1749935]). These include some of the blood coagulation and anticoagulation proteins as well as bone gamma-carboxyglutamic acid (Gla) protein (BGLAP, MIM 112260) and bone matrix protein (MGP, MIM 154870).Synonyms: GC, Gamma-glutamyl carboxylase, Vitamin K gamma glutamyl carboxylase, Vitamin K-dependent gamma-carboxylase

Gene ID: 2677

NCBI Accession: NP_000812

UniProt: P38435

Pathways: SARS-CoV-2 Protein Interactome