SERPINA1 antibody (AA 25-204)

Catalog No. ABIN4886719

Product Details anti-SERPINA1 Antibody

Target: SERPINA1 (serpin Peptidase Inhibitor, Clade A (Alpha-1 Antiproteinase, Antitrypsin), Member 1 (SERPINA1))

Binding Specificity: AA 25-204

Reactivity: Human, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SERPINA1 antibody is un-conjugated

Application: Western Blotting (WB)

Purpose: Rabbit IgG polyclonal antibody for Alpha-1-antitrypsin(SERPINA1) detection. Tested with WB in Human,Rat.

Cross-Reactivity (Details): No cross reactivity with other proteins.

Characteristics: Rabbit IgG polyclonal antibody for Alpha-1-antitrypsin(SERPINA1) detection. Tested with WB in Human,Rat.
Gene Name: serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
Protein Name: Alpha-1-antitrypsin

Purification: Immunogen affinity purified.

Immunogen: E. coli-derived human SERPINA1 recombinant protein (Position: E25-T204). Human SERPINA1 shares 72.8% amino acid (aa) sequence identity with rat SERPINA1.

Isotype: IgG

Application Details

Application Notes: WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human, Rat
Notes: Tested Species: Species with positive results.
Other applications have not been tested. Optimal dilutions should be determined by end users.

Comment:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.

References for anti-SERPINA1 antibody (ABIN4886719)

Lv, Gao, Liu, Zhang, Huang, Zhu, Zong, Li, Li: "Clinical and pathological characteristics of IgG4-related interstitial lung disease." in: Experimental and therapeutic medicine, Vol. 15, Issue 2, pp. 1465-1473, (2018) (PubMed).

Target Details for SERPINA1

Target: SERPINA1 (serpin Peptidase Inhibitor, Clade A (Alpha-1 Antiproteinase, Antitrypsin), Member 1 (SERPINA1))

Alternative Name: SERPINA1 (SERPINA1 Products)

Synonyms: AACT antibody, ACT antibody, GIG25 antibody, A1AT antibody, PI antibody, alpha-1-PI antibody, A1A antibody, AAT antibody, PI1 antibody, PRO2275 antibody, alpha1AT antibody, Pi antibody, Spi1 antibody, MGC64429 antibody, serpina1d antibody, Aps antibody, SERPINA3-5 antibody, serpin family A member 3 antibody, alpha-1-antiproteinase F precursor antibody, serpin family A member 1 antibody, alpha-1-antitrypsin antibody, calumenin antibody, serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 S homeolog antibody, serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 antibody, serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5 antibody, SH2B adaptor protein 2 antibody, serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 antibody, serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 L homeolog antibody, SERPINA3 antibody, LOC100008973 antibody, SERPINA1 antibody, LOC100328621 antibody, CALU antibody, Serpina1 antibody, serpina1.S antibody, serpina1 antibody, SPIA5 antibody, Sh2b2 antibody, Calu antibody, serpina1.L antibody

Background: SERPINA1 is also known as PI, A1A or AAT. This gene is mapped to 14q32.1. The protein encoded by this gene is secreted and is a serine protease inhibitor whose targets include elastase, plasmin, thrombin, trypsin, chymotrypsin, and plasminogen activator. Defects in this gene can cause emphysema or liver disease. Several transcript variants encoding the same protein have been found for this gene.

Synonyms: A1AT | Alpha 1 antiproteinase | Alpha 1 antitrypsin null | alpha1 antitrypsin | alpha1 PI | Alpha-1 protease inhibitor | Alpha-1-antiproteinase | Alpha-1-antitrypsin | Alpha-1-proteinase inhibitor | Serpin A1 | SERPINA 1 | SERPINA1 | Short peptide from AAT | SPAAT | P01009

Gene ID: 5265

UniProt: P01009