Unc-5 Homolog B (C. Elegans) (UNC5B) antibody

Details for Product No. ABIN4889372, Supplier: Log in to see
Antigen
  • unc5h2
  • 6330415E02Rik
  • A630020F16
  • D10Bwg0792e
  • Unc5h2
  • UNC5H2
  • p53RDL1
  • UNC5C
  • UNC5B
  • p53rdl1
  • unc-5 netrin receptor B
  • unc-5 netrin receptor B L homeolog
  • unc5b
  • Unc5b
  • UNC5B
  • unc5b.L
Reactivity
Human, Mouse (Murine), Rat (Rattus)
52
29
27
4
3
1
1
1
1
Host
Rabbit
30
20
5
Clonality
Polyclonal
Conjugate
Un-conjugated
3
3
3
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Application
ELISA, Immunohistochemistry (IHC), Western Blotting (WB)
33
31
13
3
3
1
1
1
1
1
Options
Supplier
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Immunogen UNC5B human recombinant protein
Specificity Reacts with human, mouse, rat UNC5B
Purification Purified (protein A)
Antigen
Alternative Name Netrin Receptor UNC5B (UNC5B Antibody Abstract)
Background Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Mediates apoptosis by activating DAPK1. In the absence of NTN1, activates DAPK1 by reducing its autoinhibitory phosphorylation at Ser-308 thereby increasing its catalytic activity
UniProt Q8IZJ1
Application Notes

Working dilution: Optimal dilution should be determined by the end user.
The following are guidelines only:
WB(1:500 - 1:5000) IHC(1:100 - 1:500)

Restrictions For Research Use only
Format Lyophilized
Reconstitution Must be reconstituted in distilled water to reach 1 mg/mL
Concentration 1 mg/mL
Buffer Tris 0,1M, glycine 0,1M, sucrose 2 %
Storage 4 °C/-20 °C
Storage Comment Lyophilized powder stable for a minimum of 2 years at -20°C. Store reconstituted antibodies at +4°C. For extended periods store in aliquots at -20°C. Antibodies are guaranteed for 6 month from date of receipt.
Expiry Date 24 months
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