p53 antibody (Tumor Protein P53) (Biotin)

Details for Product anti-TP53 Antibody No. ABIN4889877, Supplier: Log in to see
Antigen
  • BCC7
  • LFS1
  • P53
  • TRP53
  • p53
  • Trp53
  • brp53
  • drp53
  • etID22686.5
  • fb40d06
  • wu:fb40d06
  • zgc:111919
  • Tp53
  • bbl
  • bfy
  • bhy
  • p44
  • tp53
  • Xp53
  • TP53
  • tumor protein p53
  • cellular tumor antigen p53
  • transformation related protein 53
  • tumor protein p53 L homeolog
  • TP53
  • CpipJ_CPIJ002758
  • Tp53
  • tp53
  • Trp53
  • tp53.L
Alternatives
anti-Human p53 antibody for Immunohistochemistry (Paraffin-embedded Sections)
Reactivity
Human
2511
582
483
295
154
105
103
61
55
24
23
22
17
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14
7
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2
1
1
Host
Mouse
1506
1126
7
5
1
1
1
1
Clonality (Clone)
Monoclonal ()
Conjugate
This p53 antibody is conjugated to Biotin
79
78
67
52
45
36
34
32
23
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2
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2
Application
ELISA (Detection)
2084
960
864
777
667
647
422
294
260
155
110
90
75
41
32
19
16
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13
6
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4
3
2
1
1
1
1
1
1
1
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Options
Supplier
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Supplier Product No.
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Immunogen Recombinant p53 protein
Clone B-P3
Isotype IgG2a
Specificity Reacts with wild type and mutant p53, the epitope is within residues 18-30 of human p53
Purification Purified
Plasmids, Primers & others Plasmids, Primers & others p53 products on genomics-online (e.g. as negative or positive controls)
Antigen
Alternative Name p53 (TP53 Antibody Abstract)
Background Acts as a tumor suppressor in many tumor types, induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. In cooperation with mitochondrial PPIF is involved in activating oxidative stress-induced necrosis, the function is largely independent of transcription.
UniProt P04637
Pathways p53 Signaling, MAPK Signaling, PI3K-Akt Signaling, Apoptosis, AMPK Signaling, Chromatin Binding, ER-Nucleus Signaling, Positive Regulation of Endopeptidase Activity, Hepatitis C, Protein targeting to Nucleus, Autophagy
Application Notes

Working dilution: Optimal dilution should be determined by the end user.
The following are guidelines only :
ELISA-D0,05 - 0,5 μg/mL

Restrictions For Research Use only
Concentration 0.1 μg/μL
Buffer PBS 1 % BSA, Sodium azide 0.09 %
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C,4 °C
Storage Comment Short term storage at+4°C. For extended periods store in aliquots at -20°C. Antibodies are guaranteed for 6 months from date of receipt.
Expiry Date 6 months
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