IL21 Receptor antibody (Interleukin 21 Receptor) (AA 20-236)

Details for Product anti-IL21R Antibody No. ABIN4899488
Antigen
  • IL21R
  • il-21ra.a
  • CD360
  • NILR
  • interleukin 21 receptor
  • interleukin 21 receptor, tandem duplicate 1
  • IL21R
  • il21r.1
  • Il21r
Alternatives
anti-Human IL21 Receptor antibody for Western Blotting
Epitope
AA 20-236
15
11
9
9
8
4
3
3
3
2
2
2
1
1
1
Reactivity
Human
92
49
34
2
2
Host
Goat
93
6
5
3
Clonality
Polyclonal
Conjugate
This IL21 Receptor antibody is un-conjugated
4
2
2
2
2
2
2
1
1
1
1
1
1
1
1
Application
Cytometry by Time of Flight (CyTOF), Flow Cytometry (FACS), Western Blotting (WB)
61
40
29
13
10
9
2
2
2
1
1
Options
Immunogen S. frugiperda insect ovarian cell line Sf 21-derived recombinant human IL-21 R Subunit, Cys20-Pro236, Accession # Q9HBE5
Isotype IgG
Specificity Detects human IL-21 R Subunit in direct ELISAs and Western blots. In direct ELISAs, approximately 45 % cross-reactivity with recombinant mouse IL-21 R is observed.
Purification Immunogen affinity purified
Sterility 0.2 μm filtered
Plasmids, Primers & others Plasmids, Primers & others IL21 Receptor products on genomics-online (e.g. as negative or positive controls)
Antigen
Alternative Name IL-21 R (IL21R Antibody Abstract)
Background Alternative Names: CD360, CD360 antigen, IL-21 receptor, IL21R, IL-21R, interleukin 21 receptor, interleukin-21 receptor, MGC10967, NILR, Novel interleukin receptor
Gene ID 50615
UniProt Q9HBE5
Pathways JAK-STAT Signaling
Application Notes Western Blot 0.1 μg/mL
Flow Cytometry 2.5 μg/10^6 cells
CyTOF-ready
Restrictions For Research Use only
Reconstitution Reconstitute at 0.2 mg/mL in sterile PBS.
Buffer Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose.
Preservative Without preservative
Storage 4 °C,-20 °C,-80 °C
Storage Comment Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt,-20°C to -70°C as supplied. 1 month,2°C to 8°C under sterile conditions after reconstitution. 6 months,-20°C to -70°C under sterile conditions after reconstitution.
Expiry Date 12 months
Product cited in: Kaltenmeier, Gawanbacht, Beyer, Lindner, Trzaska, van der Merwe, Härter, Grüner, Fabricius, Lotfi, Schwarz, Schütz, Hönig, Schulz, Kern, Bommer, Schrezenmeier, Kirchhoff, Jahrsdörfer: "CD4+ T cell-derived IL-21 and deprivation of CD40 signaling favor the in vivo development of granzyme B-expressing regulatory B cells in HIV patients." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 194, Issue 8, pp. 3768-77, 2015 (PubMed). Method employed by authors: Functional Studies (Func), Functional Studies (Func), Functional Studies (Func) (Sample species: Human).

de Totero, Capaia, Fabbi, Croce, Meazza, Cutrona, Zupo, Loiacono, Truini, Ferrarini, Ferrini: "Heterogeneous expression and function of IL-21R and susceptibility to IL-21-mediated apoptosis in follicular lymphoma cells." in: Experimental hematology, Vol. 38, Issue 5, pp. 373-83, 2010 (PubMed). Method employed by authors: Western Blotting (WB), Western Blotting (WB), Western Blotting (WB) (Sample species: Human).

Ansén, Butler, Berezovskaya, Murray, Stevenson, Nadler, Hirano: "Dissociation of its opposing immunologic effects is critical for the optimization of antitumor CD8+ T-cell responses induced by interleukin 21." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 14, Issue 19, pp. 6125-36, 2008 (PubMed). Method employed by authors: Flow Cytometry (FACS), Flow Cytometry (FACS), Flow Cytometry (FACS) (Sample species: Human).

Baan, Balk, Dijke, Korevaar, Peeters, de Kuiper, Klepper, Zondervan, Maat, Weimar: "Interleukin-21: an interleukin-2 dependent player in rejection processes." in: Transplantation, Vol. 83, Issue 11, pp. 1485-92, 2007 (PubMed). Method employed by authors: Flow Cytometry (FACS), Flow Cytometry (FACS), Flow Cytometry (FACS) (Sample species: Human).

Caruso, Fina, Peluso, Fantini, Tosti, Del Vecchio Blanco, Paoluzi, Caprioli, Andrei, Stolfi, Romano, Ricci, MacDonald, Pallone, Monteleone: "IL-21 is highly produced in Helicobacter pylori-infected gastric mucosa and promotes gelatinases synthesis." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 178, Issue 9, pp. 5957-65, 2007 (PubMed). Method employed by authors: Western Blotting (WB), Western Blotting (WB), Western Blotting (WB) (Sample species: Human).

Jüngel, Distler, Kurowska-Stolarska, Seemayer, Seibl, Forster, Michel, Gay, Emmrich, Gay, Distler: "Expression of interleukin-21 receptor, but not interleukin-21, in synovial fibroblasts and synovial macrophages of patients with rheumatoid arthritis." in: Arthritis and rheumatism, Vol. 50, Issue 5, pp. 1468-76, 2004 (PubMed). Method employed by authors: Western Blotting (WB), Western Blotting (WB), Western Blotting (WB) (Sample species: Human).

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