TRKA antibody (Neurotrophic Tyrosine Kinase, Receptor, Type 1) (AA 33-407)

Details for Product anti-NTRK1 Antibody No. ABIN4900238
Antigen
  • MTC
  • TRK
  • TRK1
  • TRKA
  • Trk-A
  • p140-TrkA
  • Trk
  • C80751
  • Tkr
  • TrkA
  • trk
  • trka
  • CTRKA
  • trkA
  • neurotrophic receptor tyrosine kinase 1
  • neurotrophic tyrosine kinase, receptor, type 1
  • NTRK1
  • Ntrk1
  • ntrk1
Alternatives
anti-Human TRKA antibody for Immunoprecipitation
Epitope
AA 33-407
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1
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Reactivity
Human
468
296
237
2
2
Host
Goat
456
43
4
3
1
Clonality
Polyclonal
Conjugate
This TRKA antibody is un-conjugated
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17
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10
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2
1
1
Application
Cytometry by Time of Flight (CyTOF), Flow Cytometry (FACS), Immunohistochemistry (IHC), Neutralization (Neut), Western Blotting (WB)
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172
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88
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38
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Options
Immunogen Mouse myeloma cell line NS0-derived recombinant human TrkA, Ala33-Glu407, Accession # AAA36770
Isotype IgG
Specificity Detects human TrkA in direct ELISAs and Western blots. In direct ELISAs, approximately 50 % cross-reactivity with recombinant rat TrkA is observed and 10 % cross-reactivity with recombinant human (rh) TrkB and rhTrKC is observed.
Purification Antigen Affinity-purified
Sterility 0.2 μm filtered
Endotoxin Level <0.10 EU per 1 μg of the antibody by the LAL method.
Plasmids, Primers & others Plasmids, Primers & others TRKA products on genomics-online (e.g. as negative or positive controls)
Antigen
Alternative Name TrkA (NTRK1 Antibody Abstract)
Background Alternative Names: DKFZp781I14186, EC 2.7.10, EC 2.7.10.1, MTChigh affinity nerve growth factor receptor, Neurotrophic tyrosine kinase receptor type 1, neurotrophic tyrosine kinase, receptor, type 1, NTRK1, NTRK-1, p140-TrkA, TRK1-transforming tyrosine kinase protein, Trk-A, TRKAOncogene TRK, TRKTRK1, tyrosine kinase receptor A
Gene ID 4914
Pathways RTK Signaling, Neurotrophin Signaling Pathway, cAMP Metabolic Process
Application Notes Western Blot 1 μg/mL
Flow Cytometry 2.5 μg/10^6 cells
Immunohistochemistry 5-15 μg/mL
Neutralization 3-12 μg/mL
CyTOF-ready
Restrictions For Research Use only
Reconstitution Reconstitute at 0.2 mg/mL in sterile PBS.
Buffer Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose.
Preservative Without preservative
Storage 4 °C,-20 °C,-80 °C
Storage Comment Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt,-20°C to -70°C as supplied. 1 month,2°C to 8°C under sterile conditions after reconstitution. 6 months,-20°C to -70°C under sterile conditions after reconstitution.
Expiry Date 12 months
Supplier Images
Neutralization (Neut) image for anti-Neurotrophic Tyrosine Kinase, Receptor, Type 1 (NTRK1) (AA 33-407) antibody (ABIN4900238) Cell Proliferation Induced by beta-NGF and Neutralization by Human TrkA Antibody. Rec...
Immunohistochemistry (IHC) image for anti-Neurotrophic Tyrosine Kinase, Receptor, Type 1 (NTRK1) (AA 33-407) antibody (ABIN4900238) TrkA in Human Colon. TrkA was detected in immersion fixed paraffin-embedded sections ...
Western Blotting (WB) image for anti-Neurotrophic Tyrosine Kinase, Receptor, Type 1 (NTRK1) (AA 33-407) antibody (ABIN4900238) Detection of Human TrkA by Western Blot. Western blot shows lysates of RPMI 8226 huma...
Product cited in: Desiderio, Vermeiren, Van Campenhout, Kricha, Malki, Richts, Fletcher, Vanwelden, Schmidt, Henningfeld, Pieler, Woods, Nagy, Verfaillie, Bellefroid: "Prdm12 Directs Nociceptive Sensory Neuron Development by Regulating the Expression of the NGF Receptor TrkA." in: Cell reports, Vol. 26, Issue 13, pp. 3522-3536.e5, 2019 (PubMed). Method employed by authors: Immunocytochemistry (ICC) (Sample species: Human).

Alshawaf, Viventi, Qiu, DAbaco, Nayagam, Erlichster, Chana, Everall, Ivanusic, Skafidas, Dottori: "Phenotypic and Functional Characterization of Peripheral Sensory Neurons derived from Human Embryonic Stem Cells." in: Scientific reports, Vol. 8, Issue 1, pp. 603, 2018 (PubMed). Method employed by authors: Immunocytochemistry (ICC) (Sample species: Human).

Prencipe, Minnone, Strippoli, De Pasquale, Petrini, Caiello, Manni, De Benedetti, Bracci-Laudiero: "Nerve growth factor downregulates inflammatory response in human monocytes through TrkA." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 192, Issue 7, pp. 3345-54, 2014 (PubMed). Method employed by authors: Neutralization (Neut), Neutralization (Neut) (Sample species: Human).

Flowerdew, Wick, Himmelein, Horn, Sinicina, Strupp, Brandt, Theil, Hüfner: "Characterization of neuronal populations in the human trigeminal ganglion and their association with latent herpes simplex virus-1 infection." in: PLoS ONE, Vol. 8, Issue 12, pp. e83603, 2013 (PubMed). Method employed by authors: Immunohistochemistry (IHC), Immunohistochemistry (IHC), Immunohistochemistry (IHC) (Sample species: Human).

Huang, Lai, Wu, Cheng, Chiu: "TrkB antibody elicits cytotoxicity and suppresses migration/invasion of transitional cell carcinoma cells." in: International journal of oncology, Vol. 37, Issue 4, pp. 943-9, 2010 (PubMed). Method employed by authors: Functional Studies (Func), Functional Studies (Func), Functional Studies (Func) (Sample species: Human).

Huang, Lai, Wu, Hsu, Cheng, Lan, Chiu: "BDNF mediated TrkB activation is a survival signal for transitional cell carcinoma cells." in: International journal of oncology, Vol. 36, Issue 6, pp. 1469-76, 2010 (PubMed). Method employed by authors: Immunocytochemistry (ICC), Immunocytochemistry (ICC), Immunocytochemistry (ICC) (Sample species: Human).

Sniderhan, Garcia-Bates, Burgart, Bernstein, Phipps, Maggirwar: "Neurotrophin signaling through tropomyosin receptor kinases contributes to survival and proliferation of non-Hodgkin lymphoma." in: Experimental hematology, Vol. 37, Issue 11, pp. 1295-309, 2009 (PubMed). Method employed by authors: Immunocytochemistry (ICC), Immunocytochemistry (ICC), Immunocytochemistry (ICC) (Sample species: Human).

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