CD247 antibody (CD247 Molecule)

Details for Product anti-CD247 Antibody No. ABIN4900709, Supplier: Log in to see
Antigen
  • CD3-ZETA
  • CD3H
  • CD3Q
  • CD3Z
  • T3Z
  • TCRZ
  • 4930549J05Rik
  • A430104F18Rik
  • AW552088
  • Cd3
  • Cd3-eta
  • Cd3-zeta
  • Cd3h
  • Cd3z
  • Cd3zeta
  • T3z
  • Tcrk
  • Tcrz
  • LOC100136514
  • LOC100136549
  • LOC100305023
  • CD247
  • TCRzeta
  • CD247 molecule
  • CD247 antigen
  • CD3zeta-2
  • CD3zeta-1
  • Cd247 molecule
  • CD247
  • Cd247
  • cd3z
  • cd247
Alternatives
anti-Human CD247 antibody for Immunohistochemistry (Frozen Sections)
Reactivity
Mouse (Murine)
245
158
35
5
4
4
1
1
1
1
1
Host
Hamster
134
92
21
20
15
4
Clonality (Clone)
Monoclonal ()
Conjugate
This CD247 antibody is un-conjugated
24
12
11
10
8
8
7
7
6
6
4
4
4
4
4
4
3
3
3
3
2
2
1
1
Application
Cytometry by Time of Flight (CyTOF), Flow Cytometry (FACS), Immunoprecipitation (IP)
191
170
104
47
47
39
24
22
4
4
4
4
3
1
1
Options
Supplier
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Supplier Product No.
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Immunogen H-2Kb-specific mouse cytotoxic T-lymphocyte
Clone 145-2C11
Isotype IgG
Specificity Detects mouse CD3 epsilon . Binds to lymphocytes from all mouse strains tested and does not react with cells from rats, rabbits, miniature swine, or hamsters.1 Binds to the CD3 epsilon-chain present on T-lymphocyes and thymocytes. Its binding has been characterized with respect to several other monoclonal anti-CD3 antibodies.3,4
Purification Protein A or G purified from hybridoma culture supernatant
Sterility 0.2 μm filtered
Endotoxin Level <0.10 EU per 1 μg of the antibody by the LAL method.
Alternative Name Cd247 (CD247 Antibody Abstract)
Background Alternative Names: CD3e, CD3e antigen, CD3e antigen, epsilon polypeptide (TiT3 complex), CD3e molecule, epsilon (CD3-TCR complex), CD3-epsilon, FLJ18683, T3E, T-cell antigen receptor complex, epsilon subunit of T3, T-cell surface antigen T3/Leu-4 epsilon chain, T-cell surface glycoprotein CD3 epsilon chain, TCRE
Gene ID 916
Pathways TCR Signaling, CXCR4-mediated Signaling Events
Application Notes Flow Cytometry 2.5 μg/10^6 cells
Immunoprecipitation
Cell depletion
T Cell Stimulation 0.1-0.6 μg/mL
CyTOF-reported
Restrictions For Research Use only
Reconstitution Reconstitute at 0.5 mg/mL in sterile PBS.
Buffer Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose.
Preservative Without preservative
Storage 4 °C,-20 °C,-80 °C
Storage Comment Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt,-20°C to -70°C as supplied. 1 month,2°C to 8°C under sterile conditions after reconstitution. 6 months,-20°C to -70°C under sterile conditions after reconstitution.
Expiry Date 12 months
Supplier Images
Functional Studies (Func) image for anti-CD247 Molecule (CD247) antibody (ABIN4900709) Mouse CD3 epsilon Antibody Stimulates Cell Proliferation in Mouse T Cells. Hamster An...
Product cited in: Gupta, Marcel, Talwar, Garg, R, Perumalsamy, Sarin, Shivashankar: "Developmental heterogeneity in DNA packaging patterns influences T-cell activation and transmigration." in: PLoS ONE, Vol. 7, Issue 9, pp. e43718, 2012 (PubMed). Method employed by authors: Functional Studies (Func) (Sample species: Mouse (Murine)).

Jones, Stumhofer, Foster, Twohig, Hertzog, Topley, Williams, Hunter, Jenkins, Wang, Jones: "Naive and activated T cells display differential responsiveness to TL1A that affects Th17 generation, maintenance, and proliferation." in: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 25, Issue 1, pp. 409-19, 2011 (PubMed). Method employed by authors: Biochemical Assay (BCA) (Sample species: Mouse (Murine)).

Jones, McLoughlin, Hammond, Parker, Williams, Malhotra, Scheller, Williams, Rose-John, Topley, Jones: "Loss of CD4+ T cell IL-6R expression during inflammation underlines a role for IL-6 trans signaling in the local maintenance of Th17 cells." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 184, Issue 4, pp. 2130-9, 2010 (PubMed). Method employed by authors: Neutralization (Neut) (Sample species: Mouse (Murine)).

Sinclair, Finlay, Feijoo, Cornish, Gray, Ager, Okkenhaug, Hagenbeek, Spits, Cantrell: "Phosphatidylinositol-3-OH kinase and nutrient-sensing mTOR pathways control T lymphocyte trafficking." in: Nature immunology, Vol. 9, Issue 5, pp. 513-21, 2008 (PubMed). Method employed by authors: Functional Studies (Func) (Sample species: Mouse (Murine)).

Li, Kashiwamura, Ueda, Sekiyama, Okamura: "Protection of CD8+ T cells from activation-induced cell death by IL-18." in: Journal of leukocyte biology, Vol. 82, Issue 1, pp. 142-51, 2007 (PubMed). Method employed by authors: Functional Studies (Func) (Sample species: Mouse (Murine)).

Bheeshmachar, Purushotaman, Sade, Gunasekharan, Rangarajan, Sarin: "Evidence for a role for notch signaling in the cytokine-dependent survival of activated T cells." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 177, Issue 8, pp. 5041-50, 2006 (PubMed). Method employed by authors: Functional Studies (Func) (Sample species: Mouse (Murine)).

Ogilvie, Abelson, Hau, Vlasova, Blackshear, Bohjanen: "Tristetraprolin down-regulates IL-2 gene expression through AU-rich element-mediated mRNA decay." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 174, Issue 2, pp. 953-61, 2005 (PubMed). Method employed by authors: Functional Studies (Func) (Sample species: Mouse (Murine)).

Kipnis, Cardon, Avidan, Lewitus, Mordechay, Rolls, Shani, Schwartz: "Dopamine, through the extracellular signal-regulated kinase pathway, downregulates CD4+CD25+ regulatory T-cell activity: implications for neurodegeneration." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 24, Issue 27, pp. 6133-43, 2004 (PubMed). Method employed by authors: Functional Studies (Func) (Sample species: Mouse (Murine)).