Neurotrophin 3 antibody (AA 180-230)

Catalog No. ABIN4902031

Product Details anti-Neurotrophin 3 Antibody

Target: Neurotrophin 3 (NTF3)

Binding Specificity: AA 180-230

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Neurotrophin 3 antibody is un-conjugated

Application: ELISA, Immunocytochemistry (ICC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purpose: NT-3 is a protein encoded by the NTF3 gene which is approximately 29,4 kDa. NT-3 is secreted and is involved in apoptotic pathways in synovial fibroblasts, the GPCR pathway, ERK signalling, TGF-beta pathway and nanog in mammalian ESC pluripotency. This protein falls under the neurotrophin family. It controls survival and differentiation of mammalian neurons and is closely related to both nerve growth factor and brain-derived neurotrophic factor. It may be involved in the maintenance of the adult nervous system, and may affect development of neurons in the embryo. NT-3 is expressed in the brain and peripheral tissues. Mutations in the NTF3 gene result in diabetic neuropathy and pediatric fibrosarcoma. STJ98718 was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. This polyclonal antibody binds to endogenous NT-3.

Specificity: The antibody detects endogenous NT-3.

Characteristics: Rabbit Polyclonal to NT-3.

Purification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

Immunogen: Synthetic peptide from human NT-3 protein.

Isotype: IgG

Application Details

Application Notes: IHC-P 1:50-300
ELISA 1:5000-20000

Comment:

Brain and peripheral tissues.

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: PBS,  pH 7.4, containing 0.02 % sodium azide as Preservative and 50 % Glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze/thaw cycles.

Storage: -20 °C

Storage Comment: Store at -20°C, and avoid repeat freeze-thaw cycles.

Target Details for Neurotrophin 3

Target: Neurotrophin 3 (NTF3)

Alternative Name: NT-3 (NTF3 Products)

Synonyms: HDNF antibody, NGF-2 antibody, NGF2 antibody, NT3 antibody, NT-3 antibody, wu:fl98d04 antibody, hdnf antibody, ngf-2 antibody, ngf2 antibody, nt-3 antibody, nt3 antibody, NTF3 antibody, AI316846 antibody, AI835689 antibody, Nt3 antibody, Ntf-3 antibody, neurotrophin 3 antibody, neurotrophin 3 S homeolog antibody, neurotrophin 3 L homeolog antibody, NTF3 antibody, ntf3 antibody, ntf3.S antibody, Ntf3 antibody, ntf3.L antibody

Gene ID: 4908

UniProt: P20783

Pathways: RTK Signaling, Neurotrophin Signaling Pathway