Hemoglobin Subunit beta antibody

Catalog No. ABIN4903870

Product Details anti-Hemoglobin Subunit beta Antibody

Target: Hemoglobin Subunit beta (HBB) (Hemoglobin beta (HBB))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Hemoglobin Subunit beta antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Flow Cytometry (FACS)

Characteristics: Hemoglobin (Hgb) is coupled to four iron-binding, methene-linked tetrapyrrole rings (heme). The å (16p13.3, 5'-Ω-pseudoz-pseudo å2-pseudo å1-å2-å1-1-3') and (11p15.5) globin loci determine the basic hemoglobin structure. The globin portion of hemoglobin consists of two å chains and two chains arranged in pairs forming a tetramer. Each of the four globin chains covalently associates with a heme group. The bonds between å and chains are weaker than between similar globin chains, thereby forming a cleavage plane that is important for oxygen binding and release. High affinity for oxygen occurs upon relaxation of the å1-2 cleavage plane. When the two å1-2 interfaces are closely bound, hemoglobin has a low affinity for oxygen. Hb A, which contains two å chains plus two chains, comprises 97 % of total circulating hemoglobin. The remaining 3 % of total circulating hemoglobin is comprised of Hb A-2, which consists of two å chains plus two chains, and fetal hemoglobin (Hb F), which consists of two å chains together with two © chains.

Purification: Affinity purification

Immunogen: Recombinant protein of human HBB.

Isotype: IgG

Application Details

Application Notes: WB 1:100-1:200 , IHC 1:50-1:100 , FC 1:20-1:50

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.4

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze/thaw cycles.

Storage: -20 °C

Storage Comment: Store at -20°C.

Target Details for Hemoglobin Subunit beta

Target: Hemoglobin Subunit beta (HBB) (Hemoglobin beta (HBB))

Alternative Name: HBB (HBB Products)

Synonyms: HBB antibody, HBB1 antibody, HBBA antibody, HBBB antibody, CD113t-C antibody, beta-globin antibody, hbb antibody, hemoglobin, beta antibody, hemoglobin subunit beta antibody, hemoglobin subunit beta-like antibody, beta globin antibody, hemoglobin beta chain complex antibody, hemoglobin subunit beta-1 antibody, HBB antibody, HBB2 antibody, LOC100720944 antibody, LOC480784 antibody, Hbb antibody, LOC100136576 antibody, LOC101098159 antibody, LOC100976465 antibody, LOC100410611 antibody, LOC105468624 antibody

Target Type: Viral Protein

Gene ID: 3043

UniProt: P68871