Leptin antibody
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- Target See all Leptin (LEP) Antibodies
- Leptin (LEP)
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Reactivity
- Human, Mouse
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This Leptin antibody is un-conjugated
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Application
- Western Blotting (WB), Immunohistochemistry (IHC)
- Characteristics
- Leptin is a 16 kDa adipocyte-derived hormone that relays the status of the body's energy reserves to the hypothalamus, resulting in the suppression of appetite and modulation of energy expenditure (1,2). Leptin functions as a pleiotropic cytokine with multiple roles in immune function and reproduction (1-4). There are at least five isoforms of the leptin receptor, but only OB-Rb is signaling competent (1,2). OB-Rb is expressed on a number of cells, including T cells, B cells, keratinocytes, and others (1-6). Leptin/OB-Rb interactions induce Jak2, PI3K, Erk1/2, and Stat3 activation (1,2). OB-Rb is often highly expressed in many tumor types, including breast, pancreatic, and Tumor Initiating Stem Cells (TISCS), providing a potential mechanistic link for the tumor promoting effects of obesity (2,7).
- Purification
- Affinity purification
- Immunogen
- Recombinant protein of human LEP.
- Isotype
- IgG
- Top Product
- Discover our top product LEP Primary Antibody
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- Application Notes
- WB 1:200-1:500 , IHC 1:50-1:100
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.4
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid repeated freeze/thaw cycles.
- Storage
- -20 °C
- Storage Comment
- Store at -20°C.
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- Target
- Leptin (LEP)
- Alternative Name
- LEP (LEP Products)
- Synonyms
- ob antibody, obese antibody, LEPD antibody, OB antibody, OBS antibody, leptin antibody, Lep antibody, LEP antibody, lep antibody
- Gene ID
- 3952
- UniProt
- P41159
- Pathways
- JAK-STAT Signaling, AMPK Signaling, Hormone Transport, Peptide Hormone Metabolism, Hormone Activity, Negative Regulation of Hormone Secretion, Regulation of Carbohydrate Metabolic Process, Feeding Behaviour, Monocarboxylic Acid Catabolic Process
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