PSMC1 antibody (Proteasome (Prosome, Macropain) 26S Subunit, ATPase, 1) Primary Antibody
PSMC1 Reactivity: Human, Mouse, Rat IF, IHC, WB Host: Rabbit Polyclonal
Catalog No. ABIN4904881
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- Human, Mouse, Rat
- This PSMC1 antibody is un-conjugated
- Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blotting (WB)
- Affinity purification
- A synthetic peptide of human PSMC1
- Application Notes
- WB 1:500 - 1:2000
IHC 1:50 - 1:200
IF 1:20 - 1:50
- For Research Use only
- PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid repeated freeze/thaw cycles.
- -20 °C
- Storage Comment
- Store at -20C. Avoid freeze / thaw cycles.
- Alternative Name
- PSMC1 (PSMC1 Antibody Abstract)
- The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits, 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases which have a chaperone-like activity. This subunit and a 20S core alpha subunit interact specifically with the hepatitis B virus X protein, a protein critical to viral replication. This subunit also interacts with the adenovirus E1A protein and this interaction alters the activity of the proteasome. Finally, this subunit interacts with ataxin-7, suggesting a role for the proteasome in the development of spinocerebellar ataxia type 7, a progressive neurodegenerative disorder.
- Molecular Weight
- 49.185 kDa
- Gene ID
- Mitotic G1-G1/S Phases, DNA Replication, Synthesis of DNA
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