AFG3L2 antibody

Catalog No. ABIN4950041

Product Details anti-AFG3L2 Antibody

Target: AFG3L2 (AFG3-Like Protein 2 (AFG3L2))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This AFG3L2 antibody is un-conjugated

Application: Western Blotting (WB)

Purification: Antigen affinity

Immunogen: Amino acids R168-D250 of the human protein were used as the immunogen for the AFG3L2 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the AFG3L2 antibody should be determined by the researcher.\. Western blot: 0.1-0.5 μg/mL

Restrictions: For Research Use only

Handling

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: -20 °C

Storage Comment: After reconstitution, the AFG3L2 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Target Details for AFG3L2

Target: AFG3L2 (AFG3-Like Protein 2 (AFG3L2))

Alternative Name: AFG3L2 (AFG3L2 Products)

Synonyms: MGC147390 antibody, si:ch211-12e1.4 antibody, SCA28 antibody, SPAX5 antibody, 2310036I02Rik antibody, AW260507 antibody, Emv66 antibody, par antibody, AFG3 like matrix AAA peptidase subunit 2 antibody, AFG3-like protein 2 antibody, AFG3 ATPase family gene 3-like 2 (S. cerevisiae) antibody, AFG3-like AAA ATPase 2 antibody, AFG3-like AAA ATPase 2 L homeolog antibody, AFG3L2 antibody, LOC578526 antibody, afg3l2 antibody, afg3l2.L antibody, Afg3l2 antibody

Background: AFG3L2 is the catalytic subunit of the m-AAA protease, an ATP-dependent proteolytic complex of the mitochondrial inner membrane that degrades misfolded proteins and regulates ribosome assembly. In humans, it is encoded by the AFG3L2 gene. This gene encodes a protein localized in mitochondria and closely related to paraplegin. The paraplegin gene is responsible for an autosomal recessive form of hereditary spastic paraplegia. And this gene is a candidate gene for other hereditary spastic paraplegias or neurodegenerative disorders as well as spastic ataxia-neuropathy syndrome.

UniProt: Q9Y4W6

Pathways: Skeletal Muscle Fiber Development