KIAA1524 antibody

Catalog No. ABIN4950567

Product Details anti-KIAA1524 Antibody

Target: KIAA1524

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This KIAA1524 antibody is un-conjugated

Application: Western Blotting (WB)

Purification: Antigen affinity

Immunogen: Amino acids EVQKAQLEGRLEEKESLVKLQQEELNKHSHMIAMIH of human KIAA1524 were used as the immunogen for the CIP2A antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the CIP2A antibody should be determined by the researcher.\. Western blot: 0.1-0.5 μg/mL

Restrictions: For Research Use only

Handling

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: -20 °C

Storage Comment: After reconstitution, the CIP2A antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Target Details for KIAA1524

Target: KIAA1524

Alternative Name: CIP2A / KIAA1524 (KIAA1524 Products)

Synonyms: CIP2A antibody, p90 antibody, AA408511 antibody, AU018569 antibody, Cip2a antibody, Kiaa1524 antibody, KIAA1524 antibody, LOC100222895 antibody, RGD1310335 antibody, cell proliferation regulating inhibitor of protein phosphatase 2A antibody, RIKEN cDNA C330027C09 gene antibody, KIAA1524 antibody, cell proliferation regulating inhibitor of protein phosphatase 2A L homeolog antibody, CONSTANS interacting protein 2a antibody, CIP2A antibody, C330027C09Rik antibody, KIAA1524 antibody, cip2a.L antibody, CIP2a antibody, cip2a antibody, Cip2a antibody

Background: Protein CIP2A, also known as 'cancerous inhibitor of PP2A' and p90, is a protein that in humans is encoded by the KIAA1524 gene. It is required for the malignant cellular growth and for in vivo tumor formation. In accordance with the oncogenic role of CIP2A, overexpression promotes Ras-elicited cell growth and transforms immortalized human cells (HEK-TERVs). More recently CIP2A has been shown to regulate phosphorylation and activity of many other oncoproteins and to drive malignant cell growth and tumorigenesis in various human cancer types. Importantly, CIP2A deficient mice are viable, suggesting that targeting of oncogenic function of CIP2A would not result in serious side-effects.

UniProt: Q8TCG1