FcRn antibody (AA 54-291)

Catalog No. ABIN4951007

Product Details anti-FcRn Antibody

Target: FcRn (IgG receptor FcRn (FcRn))

Binding Specificity: AA 54-291

Reactivity: Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FcRn antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purification: Antigen affinity

Immunogen: Amino acids 54-291 of mouse FCGRT were used as the immunogen for the FCGRT antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the FCGRT antibody should be determined by the researcher.\. Western blot: 0.1-0.5 μg/mL,IHC (Paraffin): 0.5-1 μg/mL,ELISA: suitable

Restrictions: For Research Use only

Handling

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: -20 °C

Storage Comment: After reconstitution, the FCGRT antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Target Details for FcRn

Target: FcRn (IgG receptor FcRn (FcRn))

Alternative Name: FCGRT (FcRn Products)

Synonyms: FCRN antibody, alpha-chain antibody, FcRn antibody, Fc fragment of IgG receptor and transporter antibody, Fc receptor, IgG, alpha chain transporter antibody, FCGRT antibody, Fcgrt antibody

Background: IgG receptor FcRn large subunit p51 is a protein that in humans is encoded by the FCGRT gene. This gene encodes a receptor that binds the Fc region of monomeric immunoglobulin G. The encoded protein transfers immunoglobulin G antibodies from mother to fetus across the placenta. This protein also binds immunoglobulin G to protect the antibody from degradation. In addition, it is postulated that long-range cis inactivation of the FCGRT gene is responsible for hypercatabolism of IgG in myotonic dystrophy. The FCGRT gene is closely situated to the DMPK gene, which is mutant in DM.

UniProt: Q61559

Pathways: Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process