FRZB antibody (AA 176-325)

Catalog No. ABIN4951095

Product Details anti-FRZB Antibody

Target: FRZB (Frizzled-Related Protein (FRZB))

Binding Specificity: AA 176-325

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FRZB antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Purification: Antigen affinity

Immunogen: Amino acids 176-325 of human FRZB were used as the immunogen for the FRZB antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the FRZB antibody should be determined by the researcher.\. Western blot: 0.1-0.5 μg/mL,ELISA: 0.1-0.5 μg/mL (human protein tested), request BSA-free format for coating

Restrictions: For Research Use only

Handling

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: -20 °C

Storage Comment: After reconstitution, the FRZB antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Target Details for FRZB

Target: FRZB (Frizzled-Related Protein (FRZB))

Alternative Name: FRZB (FRZB Products)

Synonyms: Frp antibody, Sfrp3 antibody, frezzled antibody, fritz antibody, frzb-1 antibody, FRE antibody, FRITZ antibody, FRP-3 antibody, FRZB-1 antibody, FRZB-PEN antibody, FRZB1 antibody, FZRB antibody, OS1 antibody, SFRP3 antibody, SRFP3 antibody, hFIZ antibody, Frzb-1 antibody, frizzled-related protein antibody, Frzb antibody, FRZB antibody

Background: FRZB is also known as FRE or OS1. The protein encoded by this gene is a secreted protein that is involved in the regulation of bone development. Defects in this gene are a cause of female-specific osteoarthritis (OA) susceptibility. FRZB is a Wnt-binding protein especially important in embryonic development. It is a competitor for the cell-surface G-protein receptor Frizzled. FRZB is localized in the extracellular plasma membrane. Unlike frizzled, frzb lacks the 7 transmembrane domains normally found in G-protein-coupled receptors. It is still considered a homolog of frizzled because it contains a Cysteine Rich Domain (CRD), and because of its intracellular C-terminus which is crucial for signaling.

UniProt: Q92765

Pathways: WNT Signaling, Positive Regulation of fat Cell Differentiation