GIP antibody

Catalog No. ABIN4951171

Product Details anti-GIP Antibody

Target: GIP (Gastric Inhibitory Polypeptide (GIP))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GIP antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purification: Antigen affinity

Immunogen: Amino acids Y52-Q93 from the human protein were used as the immunogen for the GIP antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the GIP antibody should be determined by the researcher.\. Western blot: 0.1-0.5 μg/mL,IHC (FFPE): 0.5-1 μg/mL

Restrictions: For Research Use only

Handling

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: -20 °C

Storage Comment: After reconstitution, the GIP antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Target Details for GIP

Target: GIP (Gastric Inhibitory Polypeptide (GIP))

Alternative Name: GIP / Gastric inhibitory polypeptide (GIP Products)

Synonyms: GIP antibody, xgip antibody, Gludins antibody, RATGLUDINS antibody, gastric inhibitory polypeptide antibody, gastric inhibitory polypeptide L homeolog antibody, GIP antibody, gip antibody, Gip antibody, gip.L antibody

Background: Gastric inhibitory polypeptide (GIP), also known as the glucose-dependent insulinotropic peptide, is an inhibiting hormone of the secretin family of hormones. GIP is thought to have significant effects on fatty acid metabolism through stimulation of lipoprotein lipase activity in adipocytes. Additionally, GIP release has been demonstrated in the ruminant animal and may play a role in nutrient partitioning in milk production (lipid metabolism). Recently, GIP appeared as a major player in bone remodelling. It was evidenced that genetic ablation of the GIP receptor in mice resulted in profound alterations of bone microarchitecture through modification of the adipokine network. Furthermore, the deficiency in GIP receptors has also been associated in mice with a dramatic decrease in bone quality and a subsequent increase in fracture risk.

UniProt: P09681

Pathways: Positive Regulation of Peptide Hormone Secretion, Peptide Hormone Metabolism, Hormone Activity, Regulation of Lipid Metabolism by PPARalpha, Lipid Metabolism