NRIP1 antibody

Catalog No. ABIN4952410

Product Details anti-NRIP1 Antibody

Target: NRIP1 (Nuclear Receptor Interacting Protein 1 (NRIP1))

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NRIP1 antibody is un-conjugated

Application: Western Blotting (WB)

Purification: Antigen affinity

Immunogen: Amino acids EAHLQQYSREHALKTQNANQAASERLAAMARLQE of human RIP140/NRIP1 were used as the immunogen for the RIP140 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the RIP140 antibody should be determined by the researcher.\. Western blot: 0.1-0.5 μg/mL

Restrictions: For Research Use only

Handling

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: -20 °C

Storage Comment: After reconstitution, the RIP140 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Target Details for NRIP1

Target: NRIP1 (Nuclear Receptor Interacting Protein 1 (NRIP1))

Alternative Name: RIP140 / NRIP1 (NRIP1 Products)

Synonyms: MGC68665 antibody, NRIP1 antibody, RIP140 antibody, 6030458L20Rik antibody, 8430438I05Rik antibody, 9630050P12 antibody, AA959574 antibody, AW456757 antibody, nuclear receptor interacting protein 1 S homeolog antibody, nuclear receptor interacting protein 1 antibody, circumsporozoite protein antibody, nrip1.S antibody, NRIP1 antibody, nrip1 antibody, Nrip1 antibody, LOC100627733 antibody

Background: Nuclear receptor-interacting protein 1 (NRIP1), also known as receptor-interacting protein 140 (RIP140), is a protein that in humans is encoded by the NRIP1 gene. It is a nuclear protein that specifically interacts with the hormone-dependent activation domain AF2 of nuclear receptors. Also known as RIP140, this protein is a key regulator which modulates transcriptional activity of a variety of transcription factors, including the estrogen receptor. RIP140 has an important role in regulating lipid and glucose metabolism, and regulates gene expression in metabolic tissues including heart, skeletal muscle, and liver. A major role for RIP140 in adipose tissue is to block the expression of genes involved in energy dissipation and mitochondrial uncoupling, including uncoupling protein 1 and carnitine palmitoyltransferase 1b.

UniProt: P48552

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway