DLG1 antibody (AA 1-165)

Catalog No. ABIN4952462

Product Details anti-DLG1 Antibody

Target: DLG1 (Discs, Large Homolog 1 (DLG1))

Binding Specificity: AA 1-165

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DLG1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purification: Antigen affinity

Immunogen: Amino acids 1-165 of human SAP97 were used as the immunogen for the SAP97 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the SAP97 antibody should be determined by the researcher.\. Western blot: 0.1-0.5 μg/mL,IHC (Paraffin): 0.5-1 μg/mL

Restrictions: For Research Use only

Handling

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: -20 °C

Storage Comment: After reconstitution, the SAP97 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Target Details for DLG1

Target: DLG1 (Discs, Large Homolog 1 (DLG1))

Alternative Name: SAP97 / DLG1 (DLG1 Products)

Synonyms: DLG1 antibody, Dlgh1 antibody, SAP97 antibody, B130052P05Rik antibody, E-dlg/SAP97 antibody, SAP-97 antibody, mKIAA4187 antibody, DLGH1 antibody, dJ1061C18.1.1 antibody, hdlg antibody, discs large MAGUK scaffold protein 1 antibody, discs, large homolog 1 (Drosophila) antibody, DLG1 antibody, Dlg1 antibody

Background: Disks large homolog 1 (DLG1), also known as synapse-associated protein 97 or SAP97, is a protein that in humans is encoded by the SAP97 gene. SAP97 is expressed throughout the body in epithelial cells, including the kidney and brain. There is some evidence that SAP97 regulates cell-to-cell adhesion during cell death, and may interact with HPV. In the brain, SAP97's function is involved in the trafficking of transmembrane receptors from the ER to the plasma membrane. SAP97's function has been investigated by reducing its expression by knockout or increasing its expression heterologously. Mice in which the SAP97 gene has been knocked out die perinatally, have a cleft palate, and deficiencies in renal function. Overexpression of SAP97 in mammalian neurons leads to increased synaptic strength.

UniProt: Q12959

Pathways: Regulation of Actin Filament Polymerization, Cell-Cell Junction Organization, Production of Molecular Mediator of Immune Response