GLUT1 antibody (AA 92-492)

Catalog No. ABIN4952587

Product Details anti-GLUT1 Antibody

Target: GLUT1 (SLC2A1) (Solute Carrier Family 2 (Facilitated Glucose Transporter), Member 1 (SLC2A1))

Binding Specificity: AA 92-492

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GLUT1 antibody is un-conjugated

Application: Western Blotting (WB), Immunocytochemistry (ICC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Purification: Antigen affinity

Immunogen: Amino acids 92-492 of human SLC2A1 were used as the immunogen for the SLC2A1 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the SLC2A1 antibody should be determined by the researcher.\. Western blot: 0.1-0.5 μg/mL,Immunocytochemistry: 0.5-1 μg/mL,IHC (Frozen): 0.5-1 μg/mL,IHC (Paraffin): 0.5-1 μg/mL

Restrictions: For Research Use only

Handling

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: -20 °C

Storage Comment: After reconstitution, the SLC2A1 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Target Details for GLUT1

Target: GLUT1 (SLC2A1) (Solute Carrier Family 2 (Facilitated Glucose Transporter), Member 1 (SLC2A1))

Alternative Name: GLUT1 / SLC2A1 (SLC2A1 Products)

Synonyms: DYT17 antibody, DYT18 antibody, DYT9 antibody, EIG12 antibody, GLUT antibody, GLUT1 antibody, GLUT1DS antibody, HTLVR antibody, PED antibody, Glut-1 antibody, Glut1 antibody, GLUTB antibody, GTG1 antibody, Gtg3 antibody, RATGTG1 antibody, SLC2A1 antibody, GLT1 antibody, GLUCOSE TRANSPORTER 1 antibody, T21H19.70 antibody, T21H19_70 antibody, plastidic GLC translocator antibody, glut1 antibody, ped antibody, slc2a1 antibody, slc2a14 antibody, solute carrier family 2 member 1 antibody, solute carrier family 2 (facilitated glucose transporter), member 1 antibody, plastidic GLC translocator antibody, solute carrier family 2 (facilitated glucose transporter), member 1 L homeolog antibody, SLC2A1 antibody, Slc2a1 antibody, PGLCT antibody, slc2a1.L antibody

Background: GLUT1, also known as SLC2A1, is a major glucose transporter in the mammalian blood-brain barrier whose gene is mapped to 1p35-p31.3 and contains 10 exons. It is present at high levels in primate erythrocytes and brain endothelial cells. Not only can transport dehydroascorbic acid (the oxidized form of vitamin C) into the brain, GLUT1 is also likely to contribute to HTLV-associated disorders through interacting with HTLV envelope glycoproteins. Functionally, GLUT1 deficiency causes a decrease in embryonic glucose uptake and apoptosis, which may be involved in diabetic embryopathy, by contrast, an increased expression of GLUT1 in some malignant tumors may suggest a role for glucose-derivative tracers to detect in vivo thyroid cancer metastases by positron-emission tomography scanning.

UniProt: P11166

Pathways: Sensory Perception of Sound, Dicarboxylic Acid Transport, Warburg Effect