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CDKN2B antibody (AA 103-131)
CDKN2B
Reactivity: Human
WB, ELISA
Host: Rabbit
Polyclonal
unconjugated
Product Details anti-CDKN2B Antibody
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Target
See all CDKN2B Antibodies
CDKN2B
(Cyclin-Dependent Kinase Inhibitor 2B (p15, Inhibits CDK4) (CDKN2B))
Binding Specificity
All epitopes for CDKN2B antibodies
AA 103-131
Reactivity
All reactivities for CDKN2B antibodies
Human
Host
All hosts for CDKN2B antibodies
Rabbit
Clonality
All clonalities for CDKN2B antibodies
Polyclonal
Conjugate
All conjugates for CDKN2B antibodies
This CDKN2B antibody is un-conjugated
Application
All applications for CDKN2B antibodies
Western Blotting (WB), ELISA
Purification
Antigen affinity purified
Immunogen
A portion of amino acids 103-131 from the human protein was used as the immunogen for this CDKN2B antibody.
Isotype
Ig Fraction
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Alternatives
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Application Details
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Application Notes
Titration of the CDKN2B antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000
Restrictions
For Research Use only
Handling
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Format
Liquid
Buffer
In 1X PBS, pH 7.4, with 0.09 % sodium azide
Preservative
Sodium azide
Precaution of Use
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage
-20 °C
Storage Comment
Aliquot the CDKN2B antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Target Details for CDKN2B
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Target
CDKN2B
(Cyclin-Dependent Kinase Inhibitor 2B (p15, Inhibits CDK4) (CDKN2B))
Alternative Name
CDKN2B (CDKN2B Products )
Synonyms
p14-INK4b antibody, cdk4l antibody, ink4b antibody, mts2 antibody, p15 antibody, p15ink4b antibody, tp15 antibody, CDK4I antibody, INK4B antibody, MTS2 antibody, P15 antibody, TP15 antibody, p15INK4b antibody, AV083695 antibody, INK4b antibody, p15(INK4b) antibody, CDKN2A antibody, cyclin dependent kinase inhibitor 2B antibody, Cyclin-dependent kinase 4 inhibitor B antibody, cyclin-dependent kinase inhibitor 2B antibody, cyclin-dependent kinase inhibitor 2B L homeolog antibody, cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) antibody, CDKN2B antibody, cdn2b antibody, cdkn2b antibody, cdkn2b.L antibody, Cdkn2b antibody
Background
This gene lies adjacent to the tumor suppressor gene CDKN2A in a region that is frequently mutated and deleted in a wide variety of tumors. This gene encodes a cyclin-dependent kinase inhibitor, which forms a complex with CDK4 or CDK6, and prevents the activation of the CDK kinases, thus the encoded protein functions as a cell growth regulator that controls cell cycle G1 progression. The expression of this gene was found to be dramatically induced by TGF beta, which suggested its role in the TGF beta induced growth inhibition. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported.
UniProt
P42772
Pathways
Cell Division Cycle , Mitotic G1-G1/S Phases
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