NR4A2 antibody (AA 13-42)

Catalog No. ABIN3032065

Product Details anti-NR4A2 Antibody

Target: NR4A2 (Nuclear Receptor Subfamily 4, Group A, Member 2 (NR4A2))

Binding Specificity: AA 13-42

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NR4A2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Cross-Reactivity (Details): Expected species reactivity: Rat, Bovine

Purification: Purified

Immunogen: A portion of amino acids 13-42 from the human protein was used as the immunogen for this NURR1 antibody.

Isotype: Ig Fraction

Application Details

Application Notes: Titration of the NURR1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000,IHC (Paraffin): 1:50-1:100,Immunofluorescence: 1:10-1:50

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the NURR1 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Target Details for NR4A2

Target: NR4A2 (Nuclear Receptor Subfamily 4, Group A, Member 2 (NR4A2))

Alternative Name: NURR1 (NR4A2 Products)

Synonyms: nr41/42/43 antibody, Nr4a2 antibody, nurr1 antibody, not antibody, rnr1 antibody, hzf-3 antibody, tinur antibody, NGFI-B antibody, HZF-3 antibody, NOT antibody, NURR1 antibody, RNR1 antibody, TINUR antibody, Nurr1 antibody, RNR-1 antibody, TINOR antibody, ngf1b antibody, nr4a2 antibody, zgc:92696 antibody, nuclear receptor subfamily 4 group A member 2 antibody, nuclear receptor antibody, nuclear receptor subfamily 4, group A, member 2 antibody, nuclear receptor subfamily 4, group A, member 2b antibody, NR4A2 antibody, nr41/42/43 antibody, nr4a2 antibody, Nr4a2 antibody, nr4a2b antibody

Background: Parkinson's disease (PD) is a multifactorial disease that appears to arise from the effects of both genetic and environmental influences. The known genetic factors include multiple genes that have been identified in related parkinsonian syndromes, as well as alpha-synuclein. Genes associated with either PD or Parkinson-related disorders include parkin, DJ-1, ubiquitin C-terminal hydrolase isozyme L1 (UCH-L1), nuclear receptor-related factor 1 (NURR1), and alpha-synuclein. Nurr1 is a transcription factor that is expressed in the embryonic ventral midbrain and is critical for the development of dopamine (DA) neurons. It belongs to the conserved family of nuclear receptors but lacks an identified ligand and is therefore referred to as an orphan receptor. RXR ligands can promote the survival of DA neurons via a process that depends on Nurr1-RXR heterodimers. In developing DA cells, Nurr1 is required for the expression of several genes important for DA synthesis and function. Nurr1 is also important for the maintenance of adult DA neurons.

UniProt: P43354

Pathways: Nuclear Receptor Transcription Pathway, Dopaminergic Neurogenesis, Steroid Hormone Mediated Signaling Pathway