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TIGIT antibody (AA 12-142)
TIGIT
Reactivity: Human, Mouse
WB
Host: Rabbit
Polyclonal
unconjugated
Product Details anti-TIGIT Antibody
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Target
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TIGIT
(T Cell Immunoreceptor with Ig and ITIM Domains (TIGIT))
Binding Specificity
All epitopes for TIGIT antibodies
AA 12-142
Reactivity
All reactivities for TIGIT antibodies
Human, Mouse
Host
All hosts for TIGIT antibodies
Rabbit
Clonality
All clonalities for TIGIT antibodies
Polyclonal
Conjugate
All conjugates for TIGIT antibodies
This TIGIT antibody is un-conjugated
Application
All applications for TIGIT antibodies
Western Blotting (WB)
Purification
Antigen affinity
Immunogen
A portion of amino acids 12-142 from the human protein was used as the immunogen for this TIGIT antibody.
Isotype
Ig Fraction
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Alternatives
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Application Details
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Application Notes
Titration of the TIGIT antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:2000
Restrictions
For Research Use only
Handling
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Buffer
In 1X PBS, pH 7.4, with 0.09 % sodium azide
Preservative
Sodium azide
Precaution of Use
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage
-20 °C
Storage Comment
Aliquot the TIGIT antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Target Details for TIGIT
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Target
TIGIT
(T Cell Immunoreceptor with Ig and ITIM Domains (TIGIT))
Alternative Name
TIGIT (TIGIT Products )
Synonyms
VSIG9 antibody, VSTM3 antibody, WUCAM antibody, ENSMUSG00000071552 antibody, Vstm3 antibody, RGD1563191 antibody, T-cell immunoreceptor with Ig and ITIM domains antibody, T cell immunoreceptor with Ig and ITIM domains antibody, TIGIT antibody, Tigit antibody
Background
TIGIT binds with high affinity to the poliovirus receptor (PVR) which causes increased secretion of IL10 and decreased secretion of IL12B and suppresses T cell activation by promoting the generation of mature immunoregulatory dendritic cells.
UniProt
Q495A1
Pathways
Cancer Immune Checkpoints
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