beta 2 Adrenergic Receptor antibody

Catalog No. ABIN498188

Product Details anti-beta 2 Adrenergic Receptor Antibody

Target: beta 2 Adrenergic Receptor (ADRB2) (Adrenergic, beta-2-, Receptor, Surface (ADRB2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This beta 2 Adrenergic Receptor antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Specificity: This antibody detects endogenous levels of AR-β2 protein.

Cross-Reactivity (Details): Species reactivity (tested):Human.

Purification: Affinity chromatography using epitope-specific immunogen

Purity: > 95 % (by SDS-PAGE)

Application Details

Application Notes: Western blot: 1: 500 - 1: 1000. Immunohistochemistry on paraffin sections: 1: 50 - 1: 200. Immunoflourescence: 1: 50 - 1: 200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: Phosphate buffered saline (PBS) with 0.05 % sodium azide, approx. pH 7.2

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.

References for anti-beta 2 Adrenergic Receptor antibody (ABIN498188)

Müller, Schwab, Rosenfeld, Antonow-Schlorke, Nathanielsz, Rakers, Schubert, Witte, Rupprecht: "Fetal Sheep Mesenteric Resistance Arteries: Functional and Structural Maturation." in: Journal of vascular research, Vol. 54, Issue 5, pp. 259-271, (2017) (PubMed).

Target Details for beta 2 Adrenergic Receptor

Target: beta 2 Adrenergic Receptor (ADRB2) (Adrenergic, beta-2-, Receptor, Surface (ADRB2))

Alternative Name: beta-2 Adrenergic Receptor (ADRB2 Products)

Synonyms: zgc:162188 antibody, adrb2 antibody, Adrb-2 antibody, Badm antibody, Gpcr7 antibody, ADRB2R antibody, ADRBR antibody, B2AR antibody, BAR antibody, BETA2AR antibody, adrenoceptor beta 2 antibody, adrenoceptor beta 2, surface b antibody, beta2-adrenergic receptor antibody, adrenergic receptor, beta 2 antibody, ADRB2 antibody, adrb2b antibody, LOC100136153 antibody, Adrb2 antibody

Background: Beta 2 Adrenergic Receptor is a member of the G protein-coupled receptor superfamily. This receptor is directly associated with one of its ultimate effectors, the class C L-type calcium channel Ca(V)1.2. This receptor-channel complex also contains a G protein, an adenylyl cyclase, cAMP-dependent kinase, and the counterbalancing phosphatase, PP2A. The assembly of the signaling complex provides a mechanism that ensures specific and rapid signaling by this G protein-coupled receptor. This gene contains no introns in either its coding or untranslated sequences. Different polymorphic forms, point mutations, and/or downregulation of this gene are associated with nocturnal asthm,a obesity and type 2 diabetes. Expression of the beta 2 Adrenergic Receptor has been reported in adipose, blood, brain, heart, lung, nose, pancreas, skeletal muscle, skin, and vessel.Synonyms: ADRB2, ADRB2R, B2AR, Beta-2 adrenoreceptor

Molecular Weight: approx. 47 kDa

Gene ID: 154

NCBI Accession: NP_000015

UniProt: P07550

Pathways: cAMP Metabolic Process, Synaptic Membrane, Regulation of G-Protein Coupled Receptor Protein Signaling, Brown Fat Cell Differentiation