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IRX1 antibody

IRX1 Reactivity: Human, Mouse WB, IF, IHC (p) Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN498327
  • Target See all IRX1 Antibodies
    IRX1 (Iroquois Homeobox Protein 1 (IRX1))
    Reactivity
    • 25
    • 25
    • 8
    • 6
    • 5
    • 5
    • 5
    • 5
    • 4
    • 2
    • 2
    • 1
    • 1
    Human, Mouse
    Host
    • 27
    • 2
    Rabbit
    Clonality
    • 28
    • 1
    Polyclonal
    Conjugate
    • 20
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This IRX1 antibody is un-conjugated
    Application
    • 21
    • 12
    • 6
    • 5
    • 2
    • 1
    Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Specificity
    This antibody detects endogenous levels of IRX1 protein. (region surrounding Asp231)
    Cross-Reactivity (Details)
    Species reactivity (expected):Mouse.
    Species reactivity (tested):Human.
    Purification
    Affinity chromatography using epitope-specific immunogen
    Purity
    > 95 % (by SDS-PAGE)
    Top Product
    Discover our top product IRX1 Primary Antibody
  • Application Notes
    Western blot: 1: 500 - 1: 1000. Immunohistochemistry on paraffin sections: 1: 50 - 1: 200. Immunoflourescence: 1: 50 - 1: 200.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Concentration
    1.0 mg/mL
    Buffer
    Phosphate buffered saline (PBS), pH 7.2, 0.05 % sodium azide
    Preservative
    Sodium azide
    Precaution of Use
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freezing and thawing.
    Storage
    4 °C/-20 °C
    Storage Comment
    Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.
  • Target
    IRX1 (Iroquois Homeobox Protein 1 (IRX1))
    Alternative Name
    IRX1 / IRXA1 (IRX1 Products)
    Synonyms
    IRX-5 antibody, IRXA1 antibody, IRX1 antibody, Xiro antibody, Xiro1 antibody, iro1 antibody, irx-5 antibody, irx1 antibody, zgc:109702 antibody, zgc:136490 antibody, ziro1 antibody, ziro1a antibody, Xiro-1 antibody, iro1-A antibody, iro1-B antibody, irx1-a antibody, irx1-b antibody, iroquois homeobox 1 antibody, Iroquois related homeobox 1 (Drosophila) antibody, iroquois homeobox 1a antibody, iroquois homeobox 1 L homeolog antibody, Putative iroquois-class homeodomain protein irx-1 antibody, iroquois homeobox 1 S homeolog antibody, IRX1 antibody, Irx1 antibody, irx1 antibody, irx1a antibody, irx1.L antibody, irx-1 antibody, irx1.S antibody
    Background
    The Iroquois homeobox gene family of transcription factors regulate aspects of embryonic development including anterior/posterior and dorsal/ventral axis patterning in the central nervous system. The Iroquois family are clustered on two loci, IRXA and IRXB, which map to chromosomes 8 and 13 in mice. The IRXA group includes Irx1, Irx2 and Irx4, the IRXB group is comprises Irx3, Irx5 and Irx6. Irx1 and Irx2 are both widely expressed during development in the lung epithelium and also in the ventricular septum. Irx1 and Irx2 also play a role in digit formation (E11.5-E14.5). The Irx gene family members are each expressed in a distinct pattern during mouse heart development. Specifically, Irx1 and Irx2 are expressed in the ventricular septum and Irx3 is expressed in the ventricular trabeculated myocardium. In addition, Irx4 is expressed in the linear heart tube and the AV canal, Irx5 is expressed in the endocardium lining the ventricular and atrial myocardium. Furthermore, the IRX4 gene may modulate cardiac development and function. Although the heart of Irx4- mice appears to develop normally, adult Irx4- mice exhibit cardiomyopathy, including cardiac hypertrophy and decreased contractility.Synonyms: Homeodomain protein IRXA1, IRX-1, Iroquois homeobox protein 1, Iroquois-class homeodomain protein IRX-1
    Molecular Weight
    approx. 47 kDa
    Gene ID
    79192
    NCBI Accession
    NP_077313
    UniProt
    P78414
    Pathways
    Tube Formation
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