MEIS1 antibody

Catalog No. ABIN498509

Product Details anti-MEIS1 Antibody

Target: MEIS1 (Meis Homeobox 1 (MEIS1))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MEIS1 antibody is un-conjugated

Application: Western Blotting (WB)

Specificity: This antibody detects endogenous levels of Meis1 protein. (region surrounding Ile278)

Cross-Reactivity (Details): Species reactivity (tested):Human, Mouse.

Purification: Affinity chromatography

Purity: > 95 % by SDS-PAGE

Application Details

Application Notes: Western Blot: 1/500 - 1/1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 1,0 mg/mL

Buffer: Phosphate buffered saline (PBS), pH 7.2., 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for MEIS1

Target: MEIS1 (Meis Homeobox 1 (MEIS1))

Alternative Name: MEIS1 (MEIS1 Products)

Synonyms: meis antibody, 1323/07 antibody, 1422/04 antibody, CG17117 antibody, Dm-HTH antibody, Dmel\\CG17117 antibody, HTH antibody, Hth antibody, Meis1 antibody, P53 antibody, anon-EST:Liang-2.13 antibody, clone 2.13 antibody, dtl antibody, hth1 antibody, hth2 antibody, l(3)05745 antibody, l(3)86Ca antibody, cb224 antibody, id:ibd5078 antibody, meis1.1 antibody, wu:fb38b03 antibody, wu:fc02e11 antibody, wu:fd12a02 antibody, C530044H18Rik antibody, Evi8 antibody, Meis homeobox 1 antibody, Meis homeobox 1 S homeolog antibody, homothorax antibody, Meis homeobox 1 b antibody, MEIS1 antibody, meis1.S antibody, Meis1 antibody, hth antibody, meis1b antibody, meis1 antibody

Background: Hox, Pbx, and Meis families of transcription factors form heteromeric complexes and bind DNA through specific homeobox domains. Hox proteins are involved in regulating tissue patterning during development, and they are also expressed n lineage- and stage-specific patterns during adult ematopoietic ifferentiation and in leukemias. The Hox proteins, which include paralog groups 1 to 10, have a low intrinsic binding affinity for DNA and are instead associated into cooperative DNA binding complexes with Pbx or the Pbx related Meis proteins, which result in an enhanced Hox-DNA binding affinity and an increased selectivity for the binding site. Both Meis1 and 2 (also known as Meis-related gene 1) are members of the TALE (three amino acid loop extension) family of homeodomain-containing proteins. In addition to binding with Hox proteins, Meis1 also forms heterodimers with the ubiquitously expressed Pbx proteins, including Pbx1, Pbx2 and Pbx3, and these complexes contain distinct DNA-binding specificities.Synonyms: Homeobox protein Meis1

Molecular Weight: approx. 37 kDa

Gene ID: 4211

NCBI Accession: NP_002389

UniProt: O00470

Pathways: Chromatin Binding