RPSA/Laminin Receptor antibody

Catalog No. ABIN498680

Product Details anti-RPSA/Laminin Receptor Antibody

Target: RPSA/Laminin Receptor (RPSA) (Ribosomal Protein SA (RPSA))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RPSA/Laminin Receptor antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Specificity: This antibody detects endogenous levels of Laminin-R protein. (region surrounding Gln215)

Cross-Reactivity (Details): Species reactivity (expected):Mouse and Rat.
Species reactivity (tested):Human.

Purification: Affinity chromatography

Purity: > 95 % by SDS-PAGE

Application Details

Application Notes: Western Blot: 1/500 - 1/1000. Immunohistochemistry: 1/50 - 1/200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 1,0 mg/mL

Buffer: Phosphate buffered saline (PBS), pH 7.2., 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for RPSA/Laminin Receptor

Target: RPSA/Laminin Receptor (RPSA) (Ribosomal Protein SA (RPSA))

Alternative Name: RPSA (RPSA Products)

Synonyms: 37LRP antibody, 67LR antibody, LBP/p40 antibody, LRP/LR antibody, LamR antibody, rpsa antibody, LamR1 antibody, RPSA antibody, LAMBR antibody, LAMR1 antibody, LBP antibody, LRP antibody, NEM/1CHD4 antibody, SA antibody, lamR antibody, p40 antibody, 67kDa antibody, 67lr antibody, AL022858 antibody, Lamr antibody, Lamr1 antibody, Lamrl1 antibody, MLR antibody, P40 antibody, P40-3 antibody, P40-8 antibody, lamr1 antibody, zgc:55831 antibody, zgc:77824 antibody, DMRT1 antibody, 40S ribosomal protein SA antibody, 67kD laminin receptor antibody, ribosomal protein SA antibody, rssa antibody, rpsa antibody, RPSA antibody, Rpsa antibody, LOC100144340 antibody

Background: Laminin receptor (Laminin-R) has a heterodimeric structure similar to that of receptors for other extracellular matrix proteins such as Fibronectin and Vitronectin. Incorporation of Laminin-R into lysosomal membranes makes it possible for lysosomes to attach to surfaces coated with Laminin. This and other properties identify Laminin-R as a member of the integrin family of cell adhesion receptors. The Laminin-R precursor is a polypeptide whose expression is consistently upregulated in aggressive carcinoma. The precursor, which is also identified as p40 ribosome-associated protein, appears to be a multifunctional protein involved in the translational machinery. Laminin-R (also known as colon carcinoma Laminin-binding protein) is found at nine-fold higher levels in colon carcinoma than in adjacent normal colonic epithelium. Addi-tionally, the level of the Laminin-R is higher in the lung cancer cell line than in the lung cell line.Synonyms: 37 kDa laminin receptor precursor, 37/67 kDa laminin receptor, 37LRP, 40S ribosomal protein SA, 67 kDa laminin receptor, 67LR, Colon carcinoma laminin-binding protein, LAMBR, LAMR1, LRP/LR, LamR, Laminin receptor 1, Laminin-binding protein precursor p40, NEM/1CHD4

Molecular Weight: approx. 40 kDa

Gene ID: 3921

NCBI Accession: NP_001012321

UniProt: P08865

Pathways: Ribonucleoprotein Complex Subunit Organization, Ribosome Assembly