IQCB1 antibody

Catalog No. ABIN498968

Product Details anti-IQCB1 Antibody

Target: IQCB1 (IQ Motif Containing B1 (IQCB1))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This IQCB1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Specificity: This antibody detects endogenous levels of Nephrocystin-5 protein. (region surrounding Arg467)

Cross-Reactivity (Details): Species reactivity (tested):Human, Mouse.

Purification: Affinity chromatography

Purity: > 95 % by SDS-PAGE

Application Details

Application Notes: Western Blot: 1/500 - 1/1000. Immunohistochemistry: 1/50 - 1/200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 1,0 mg/mL

Buffer: Phosphate buffered saline (PBS), pH 7.2., 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for IQCB1

Target: IQCB1 (IQ Motif Containing B1 (IQCB1))

Alternative Name: IQCB1 (IQCB1 Products)

Synonyms: piq antibody, nphp5 antibody, slsn5 antibody, MGC81507 antibody, IQCB1 antibody, zgc:101792 antibody, MGC146213 antibody, 6820449I09Rik antibody, AV128382 antibody, NPHP5 antibody, PIQ antibody, SLSN5 antibody, IQ motif containing B1 antibody, IQ motif containing B1 L homeolog antibody, IQ calmodulin-binding motif containing 1 antibody, Iqcb1 antibody, iqcb1.L antibody, IQCB1 antibody, iqcb1 antibody

Background: CEP290 activates ATF4 mediated transcription and is required for the correct localization of ciliary and phototransduction proteins in retinal photoreceptor cells, may play a role in ciliary transport processes. CEP290 is ubiquitously expressed, strongly in placenta and weakly in brain. There are two named isoforms. Defects in CEP290 are a cause of Joubert syndrome type 5 (JBTS5) [MIM:610188], Senior-Loken syndrome type 6 (SLSN6) [MIM:610189], Leber congenital amaurosis type 10 (LCA10) [MIM:611755] and Meckel syndrome type 4 (MKS4) [MIM:611134]. Antibodies against CEP290 are present in sera from patients with cutaneous T cell lymphomas, but not in the healthy control population.Synonyms: IQ calmodulin-binding motif-containing protein 1, KIAA0036, NPHP5, OK/SW-cl.85

Molecular Weight: approx. 69 kDa

Gene ID: 9657

NCBI Accession: NP_001018864

UniProt: Q15051