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DPYSL4 antibody

DPYSL4 Reactivity: Human, Mouse, Rat WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN499060
  • Target See all DPYSL4 Antibodies
    DPYSL4 (Dihydropyrimidinase-Like 4 (DPYSL4))
    Reactivity
    • 29
    • 13
    • 13
    • 5
    • 5
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    Human, Mouse, Rat
    Host
    • 25
    • 4
    Rabbit
    Clonality
    • 27
    • 2
    Polyclonal
    Conjugate
    • 17
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This DPYSL4 antibody is un-conjugated
    Application
    • 17
    • 15
    • 3
    • 3
    • 1
    • 1
    Western Blotting (WB)
    Specificity
    This antibody detects endogenous levels of CRMP-3 protein. (region surrounding Cys132)
    Cross-Reactivity (Details)
    Species reactivity (expected):Mouse and Rat.
    Species reactivity (tested):Human.
    Purification
    Affinity chromatography
    Purity
    > 95 % by SDS-PAGE
    Top Product
    Discover our top product DPYSL4 Primary Antibody
  • Application Notes
    Western Blot: 1/500 - 1/1000.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Concentration
    1,0 mg/mL
    Buffer
    Phosphate buffered saline (PBS), pH 7.2., 15 mM sodium azide
    Preservative
    Sodium azide
    Precaution of Use
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freezing and thawing.
    Storage
    4 °C/-20 °C
    Storage Comment
    Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
  • Target
    DPYSL4 (Dihydropyrimidinase-Like 4 (DPYSL4))
    Alternative Name
    DPYSL4 / CRMP3 (DPYSL4 Products)
    Synonyms
    CRMP3A antibody, CRMP3B antibody, crmp3 antibody, crmp3-a antibody, MGC53768 antibody, DPYSL4 antibody, drp-4 antibody, ulip4 antibody, CRMP-3 antibody, CRMP3 antibody, DRP-4 antibody, ULIP4 antibody, AI173505 antibody, Crmp3 antibody, DPY4 antibody, Drp-4 antibody, Ulip4 antibody, Dpys4 antibody, dihydropyrimidinase like 4 antibody, dihydropyrimidinase like 4 L homeolog antibody, dihydropyrimidinase-like 4 antibody, DPYSL4 antibody, dpysl4.L antibody, dpysl4 antibody, Dpysl4 antibody
    Background
    Collapsin response mediator proteins (CRMPs), including CRMP-1 (DRP-1), CRMP-2 (DRP-2 or TOAD64), CRMP-3 (DRP-4), CRMP-4 (DRP-3) and CRMP-5 (DRP-5), mediate signal transduction after exposure of neural cells to the axon guidance molecule Semaphorin 3A (SEMA3A)/collapsin. CRMPs are present in the developing cerebral cortex and neocortical neurons and are responsive to Semaphorin 3A. In the adult brain, the expression of CRMPs is dramatically downregulated. However, they remain expressed in structures that retain their capacity for differentiation and plasticity. CRMP-3 is expressed transiently in developing spinal cord and selectively in the postnatal cerebellum. It is cleaved by Calpain to produce a p54 N-terminal fragment. This cleavage product translocates to the nucleus and induces neuronal death in response to excitotoxicity and cerebral ischemia.Synonyms: Collapsin response mediator protein 3, DRP-4, Dihydropyrimidinase-related protein 4, ULIP4, UNC33-like phosphoprotein 4
    Molecular Weight
    approx. 50 kDa
    Gene ID
    10570
    NCBI Accession
    NP_006417
    UniProt
    O14531
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