TNFRSF17
Reactivity: Human
WB, ELISA
Host: Mouse
Monoclonal
3H6
unconjugated
Application Notes
ELISA. Western Blot: BCMA antibody can be used for detection of BCMA at 2 to 5 μg/mL. Immunohistochemistry. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions
For Research Use only
Buffer
PBS containing 0.02 % sodium azide.
Preservative
Sodium azide
Precaution of Use
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage
4 °C
Storage Comment
Store the antibody undiluted at 2-8 °C.
Target
BCMA (TNFRSF17)
(Tumor Necrosis Factor Receptor Superfamily, Member 17 (TNFRSF17))
Members in the TNF superfamily regulate immune responses and induce apoptosis. Two novel members in the TNF family were recently identified and designated BAFF/BLyS/TALL-1/THANK/zTNF4 (1-4) and April/TALL-2, respectively, (3,5). BAFF was characterized as a B cell activator since it induced B cell proliferation and immunoglobulin secretion (1,2). April regulates immunological and non-immunological cell growth. Three receptors, BCMA (for B cell maturation protein), TACI, and BAFF-R, for BAFF were recently identified (6,7). BCMA, like TACI, binds BAFF and April. BAFF and its receptors induce B cell development and survival, activate NF-kB and c-jun N-terminal kinase, and are involved in B cell associated autoimmune diseases.Synonyms: B-cell maturation protein, BCM, TNFRSF17, Tumor necrosis factor receptor superfamily member 17