BICD1 antibody (C-Term)

Catalog No. ABIN499455

Product Details anti-BICD1 Antibody

Target: BICD1 (Bicaudal D Homolog 1 (BICD1))

Binding Specificity: C-Term

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This BICD1 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), Enzyme Immunoassay (EIA)

Specificity: This antibody reacts to BICD1. This antibody will only recognize the larger isoform.

Purification: Affinity chromatography purified via peptide column

Immunogen: BICD1 antibody was raised against a 15 amino acid peptide from near the carboxy terminus of human BICD1.

Isotype: IgG

Application Details

Application Notes: ELISA. Western Blot: BICD1 antibody can be used for detection of BICD1 at 0.5 - 1 μg/mL. Immunocytochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Buffer: PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Store the antibody undiluted at 2-8 °C.

Target Details for BICD1

Target: BICD1 (Bicaudal D Homolog 1 (BICD1))

Alternative Name: BICD1 (BICD1 Products)

Synonyms: BICD antibody, B830009D06Rik antibody, mKIAA4125 antibody, bicaudal D homolog 1 L homeolog antibody, BICD cargo adaptor 1 antibody, bicaudal D homolog 1 (Drosophila) antibody, bicd1.L antibody, BICD1 antibody, Bicd1 antibody

Background: BICD1 was initially identified as the human homolog to Drosophila Bicaudal-D protein that forms part of the cytoskeleton and mediates the correct sorting of mRNAs for oocyte- and axis-determining factors during oogenesis. BICD1 can bind to dynein-dynactin and co-localizes with Rab6A on the trans-Golgi network and cytoplasmic vesicles, suggesting BICD1 regulates COPI-independent Golgi-ER transport. BICD1 will also interact with Rab6B, a Rab6 isoform that is expressed primarily in brain. Live cell imaging showed bi-directional movement of Rab6B structures in SK-N-SH neurites, indicating that BICD1 is involved in the Rab6B regulation of retrograde cargo transport in neuronal cells. At least two isoforms of BICD1 are known to exist.Synonyms: Bic-D1, Protein bicaudal D homolog 1

Gene ID: 636

NCBI Accession: NP_001705

UniProt: Q96G01

Pathways: Ribonucleoprotein Complex Subunit Organization, Regulation of G-Protein Coupled Receptor Protein Signaling, Maintenance of Protein Location