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BICD2 antibody (Center)

BICD2 Reactivity: Human, Mouse, Rat WB, EIA Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN499459
  • Target See all BICD2 Antibodies
    BICD2 (Bicaudal D Homolog 2 (BICD2))
    Binding Specificity
    • 5
    • 4
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    Center
    Reactivity
    • 24
    • 4
    • 4
    • 2
    • 2
    Human, Mouse, Rat
    Host
    • 22
    • 2
    Rabbit
    Clonality
    • 22
    • 2
    Polyclonal
    Conjugate
    • 15
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This BICD2 antibody is un-conjugated
    Application
    • 13
    • 6
    • 5
    • 4
    • 3
    • 2
    • 2
    • 1
    Western Blotting (WB), Enzyme Immunoassay (EIA)
    Specificity
    This antibody reacts to BICD2. This BICD2 antibody will not cross-react with BICD1.
    Purification
    Affinity chromatography purified via peptide column
    Immunogen
    BICD2 antibody was raised against a 14 amino acid peptide from near the center of human BICD2.
    Isotype
    IgG
    Top Product
    Discover our top product BICD2 Primary Antibody
  • Application Notes
    ELISA. Western Blot: BICD2 antibody can be used for detection of BICD2 at 1 - 2 μg/mL.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Buffer
    PBS containing 0.02 % sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C
    Storage Comment
    Store the antibody undiluted at 2-8 °C.
  • Target
    BICD2 (Bicaudal D Homolog 2 (BICD2))
    Alternative Name
    BICD2 (BICD2 Products)
    Synonyms
    SMALED2 antibody, bA526D8.1 antibody, 0610027D24Rik antibody, 1110005D12Rik antibody, AA408834 antibody, mKIAA0699 antibody, MGC84972 antibody, BICD2 antibody, bicd2 antibody, BICD cargo adaptor 2 antibody, bicaudal D homolog 2 (Drosophila) antibody, BICD cargo adaptor 2 L homeolog antibody, zgc:171572 antibody, BICD2 antibody, Bicd2 antibody, bicd2.L antibody, bicd2 antibody, zgc:171572 antibody
    Background
    BICD2 is the second human homolog discovered to the Drosophila Bicaudal-D protein that forms part of the cytoskeleton and mediates the correct sorting of mRNAs for oocyte- and axis-determining factors during oogenesis. Similar to the highly homologous protein BICD1, BICD2 can bind to dynein-dynactin complex, primarily through the dynamitin subunit of dynactin. The C-terminus of BICD2 targets the protein to the Golgi complex while the N-terminal domain of BICD2 co-immunoprecipitates with cytoplasmic dynein, suggesting BICD2 plays a role in the dynein-dynactin interaction on the surface of membranous organelles. Mice engineered to overexpress the BICD2 amino terminal domain in neurons developed amyotrophic lateral sclerosis (ALS)-like features such as Golgi fragmentation, neurofilament swelling in proximal axons, etc., suggesting that impaired dynein/dynactin function may explain some of the pathological features observed in ALS patients.Synonyms: Bic-D2, KIAA0699, Protein bicaudal D homolog 2
    Gene ID
    23299
    UniProt
    Q8TD16
    Pathways
    Maintenance of Protein Location
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