ADAMTS8 antibody (AA 541-640) (Alexa Fluor 750)

Catalog No. ABIN4996076

Product Details anti-ADAMTS8 Antibody (Alexa Fluor 750)

Target: ADAMTS8 (ADAM Metallopeptidase with thrombospondin Type 1 Motif, 8 (ADAMTS8))

Binding Specificity: AA 541-640

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ADAMTS8 antibody is conjugated to Alexa Fluor 750

Application: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Predicted Reactivity: Human,Mouse,Rat,Dog,Pig,Horse,Chicken

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human ADAMTS8

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for ADAMTS8

Target: ADAMTS8 (ADAM Metallopeptidase with thrombospondin Type 1 Motif, 8 (ADAMTS8))

Alternative Name: ADAMTS8 (ADAMTS8 Products)

Synonyms: ADAMTS8 antibody, METH-2 antibody, METH2 antibody, ADAM-TS8 antibody, ADAM metallopeptidase with thrombospondin type 1 motif 8 antibody, a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 8 antibody, ADAM metallopeptidase with thrombospondin type 1 motif, 8 antibody, ADAMTS8 antibody, adamts8 antibody, Adamts8 antibody

Background:

Synonyms: A disintegrin and metalloproteinase with thrombospondin mots 8, ADAMTS 8, METH 2, METH 8, METH8, A disintegrin like and metalloprotease reprolysin type with thrombospondin type 1 mot 8, A disintegrin like and metalloprotease with thrombospondin type 1 mot 8, ADAM metallopeptidase with thrombospondin type 1 mot 8, ADAM TS 8, ADAM TS8, METH2, ATS8_HUMAN.

Background: ADAMTS proteases are secreted enzymes containing a prometalloprotease domain of the reprolysin type. The ADAMTS proteases function in processing of procollagens and von Willebrand factor as well as catabolism of aggrecan, versican and brevican. They have been demonstrated to have important roles in connective tissue organization, coagulation, inflammation, arthritis, angiogenesis and cell migration.A member of the metalloproteinase family containing disintegrin like domains (ADAMs), the function of ADAMTS8 is still poorly understood. ADAMTS8 contains the canonical HExxHxxxxxH zinc metalloproteinase motif, and has been shown to be proteolytically active on a range of substrates. ADAMTS8 is inhibited by the endogenous MMP inhibitors, TIMP1, 2, 3 and 4, but most efficiently by TIMP3. In addition to the metalloprotease domain, ADAMTS8 has a propeptide domain, a Prohormone Convertase (PC, furin) cleavage site, a cysteine rich domain and thrombospondin 1 like domains.

Gene ID: 11095