FAM134C antibody (AA 76-180) (Alexa Fluor 750)

Catalog No. ABIN5002364

Product Details anti-FAM134C Antibody (Alexa Fluor 750)

Target: FAM134C (Family with Sequence Similarity 134, Member C (FAM134C))

Binding Specificity: AA 76-180

Reactivity: Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FAM134C antibody is conjugated to Alexa Fluor 750

Application: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Cross-Reactivity: Mouse

Predicted Reactivity: Human,Rat,Dog,Cow,Sheep,Pig,Horse,Rabbit,Guinea Pig

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human FAM134C

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for FAM134C

Target: FAM134C (Family with Sequence Similarity 134, Member C (FAM134C))

Alternative Name: FAM134C (FAM134C Products)

Synonyms: 1300010M03Rik antibody, 4933404C01Rik antibody, AI551748 antibody, RGD1561189 antibody, reticulophagy regulator family member 3 antibody, RETREG3 antibody, Retreg3 antibody

Background:

Synonyms: Protein FAM134C, FAM134C

Background: Chromosome 17 makes up over 2.5 % of the human genome with about 81 million bases encoding over 1,200 genes. Two key tumor suppressor genes are associated with chromosome 17, namely, p53 and BRCA1. Tumor suppressor p53 is necessary for maintenance of cellular genetic integrity by moderating cell fate through DNA repair versus cell death. Malfunction or loss of p53 expression is associated with malignant cell growth and Li-Fraumeni syndrome. Like p53, BRCA1 is directly involved in DNA repair, though specifically it is recognized as a genetic determinant of early onset breast cancer and predisposition to cancers of the ovary, colon, prostate gland and fallopian tubes. Chromosome 17 is also linked to neurofibromatosis, a condition characterized by neural and epidermal lesions, and dysregulated Schwann cell growth. Alexander disease, Birt-Hogg-Dube syndrome and Canavan disease are also associated with chromosome 17. The FAM134C gene product has been provisionally designated FAM134C pending further characterization.

Gene ID: 162427

UniProt: Q86VR2

Pathways: SARS-CoV-2 Protein Interactome